| http://purl.uniprot.org/citations/22987638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22987638 | http://www.w3.org/2000/01/rdf-schema#comment | "Developmental arrest of Blimp1/Prdm1 mutant embryos at around embryonic day 10.5 (E10.5) has been attributed to placental disturbances. Here we investigate Blimp1/Prdm1 requirements in the trophoblast cell lineage. Loss of function disrupts specification of the invasive spiral artery-associated trophoblast giant cells (SpA-TGCs) surrounding maternal blood vessels and severely compromises the ability of the spongiotrophoblast layer to expand appropriately, secondarily causing collapse of the underlying labyrinth layer. Additionally, we identify a population of proliferating Blimp1(+) diploid cells present within the spongiotrophoblast layer. Lineage tracing experiments exploiting a novel Prdm1.Cre-LacZ allele demonstrate that these Blimp1(+) cells give rise to the mature SpA-TGCs, canal TGCs, and glycogen trophoblasts. In sum, the transcriptional repressor Blimp1/Prdm1 is required for terminal differentiation of SpA-TGCs and defines a lineage-restricted progenitor cell population contributing to placental growth and morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/22987638 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.199828.112"xsd:string |
| http://purl.uniprot.org/citations/22987638 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/22987638 | http://purl.uniprot.org/core/author | "Robertson E.J."xsd:string |
| http://purl.uniprot.org/citations/22987638 | http://purl.uniprot.org/core/author | "Morgan M.A."xsd:string |
| http://purl.uniprot.org/citations/22987638 | http://purl.uniprot.org/core/author | "Bikoff E.K."xsd:string |
| http://purl.uniprot.org/citations/22987638 | http://purl.uniprot.org/core/author | "Mould A."xsd:string |
| http://purl.uniprot.org/citations/22987638 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22987638 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/22987638 | http://purl.uniprot.org/core/pages | "2063-2074"xsd:string |
| http://purl.uniprot.org/citations/22987638 | http://purl.uniprot.org/core/title | "Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta."xsd:string |
| http://purl.uniprot.org/citations/22987638 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/22987638 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22987638 |
| http://purl.uniprot.org/citations/22987638 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22987638 |
| http://purl.uniprot.org/uniprot/Q60636#attribution-1D986729D66DFBC0939677E9E5C1227C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22987638 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWD0-mappedCitation-22987638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22987638 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1L0-mappedCitation-22987638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22987638 |
| http://purl.uniprot.org/uniprot/#_A0A0M6L0K6-mappedCitation-22987638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22987638 |
| http://purl.uniprot.org/uniprot/#_A0A0M6L0W4-mappedCitation-22987638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22987638 |
| http://purl.uniprot.org/uniprot/#_A0A0M6L0X8-mappedCitation-22987638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22987638 |
| http://purl.uniprot.org/uniprot/#_A0A0M5HDY7-mappedCitation-22987638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22987638 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQV9-mappedCitation-22987638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22987638 |
| http://purl.uniprot.org/uniprot/#_D3YW03-mappedCitation-22987638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22987638 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VLI3-mappedCitation-22987638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22987638 |