| http://purl.uniprot.org/citations/22988097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22988097 | http://www.w3.org/2000/01/rdf-schema#comment | "MHC class II-expressing thymocytes and thymic epithelial cells can mediate CD4 T-cell selection resulting in functionally distinct thymocyte-selected CD4 (T-CD4) and epithelial-selected CD4 (E-CD4) T cells, respectively. However, little is known about how T-cell receptor (TCR) signaling influences the development of these two CD4 T-cell subsets. To study TCR signaling for T-CD4 T-cell development, we used a GFP reporter system of Nur77 in which GFP intensity directly correlates with TCR signaling strength. T-CD4 T cells expressed higher levels of GFP than E-CD4 T cells, suggesting that T-CD4 T cells received stronger TCR signaling than E-CD4 T cells during selection. Elimination of Ras GTPase-activating protein enhanced E-CD4 but decreased T-CD4 T-cell selection efficiency, suggesting a shift to negative selection. Conversely, the absence of IL-2-inducible T-cell kinase that causes poor E-CD4 T-cell selection due to insufficient TCR signaling improved T-CD4 T-cell generation, consistent with rescue from negative selection. Strong TCR signaling during T-CD4 T-cell development correlates with the expression of the transcription factor promyelocytic leukemia zinc finger protein. However, although modulation of the signaling strength affected the efficiency of T-CD4 T-cell development during positive and negative selection, the signaling strength is not as important for the effector function of T-CD4 T cells. These findings indicate that innate T-CD4 T cells, together with invariant natural killer T cells and γδ T cells, receive strong TCR signals during their development and that signaling requirements for the development and the effector functions are distinct."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1207528109"xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Chang C.H."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Qiao Y."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Mueller K."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Schwartzberg P.L."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Wiest D.L."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "King P.D."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Lapinski P.E."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Kappes D.J."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Horai R."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Teh H.S."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Sant'Angelo D.B."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Hogquist K.A."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Stritesky G.L."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/author | "Sofi H."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/pages | "16264-16269"xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/title | "Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells."xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/22988097 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22988097 |