| http://purl.uniprot.org/citations/22989614 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22989614 | http://www.w3.org/2000/01/rdf-schema#comment | "Monocyte chemotactic protein-1 (MCP-1), also known as "chemokine ligand 2" (CCL2), is a monocyte-attracting chemokine produced in lung epithelial cells. We previously reported an association of increased levels of plasma MCP-1 with primary graft dysfunction (PGD) after lung transplantation in a nested case-control study of extreme phenotypes using a multiplex platform. In this study, we sought to evaluate the role of plasma MCP-1 level as a biomarker across the full spectrum of PGD. We performed a prospective cohort study of 108 lung transplant recipients within the Lung Transplant Outcomes Group cohort. Plasma MCP-1 levels were measured pretransplantation and 6 and 24 hours after transplantation. The primary outcome was development of grade 3 PGD within 72 hours of transplant, with secondary analyses at the 72-hour time point. Multivariable logistic regression was used to evaluate confounding. Thirty subjects (28%) developed PGD. Median MCP-1 measured at 24 hours post-transplant was elevated in subjects with PGD (167.95 vs 103.5 pg/mL, P = .04). MCP-1 levels at 24 hours were associated with increased odds of grade 3 PGD after lung transplantation (odds ratio for each 100 pg/mL, 1.24; 95% confidence interval, 1.00-1.53) and with grade 3 PGD present at the 72-hour time point (odds ratio for each 100 pg/mL, 1.57; 95% confidence interval, 1.18-2.08), independent of confounding variables in multivariable analyses. MCP-1 levels measured preoperatively and 6 hours after transplant were not significantly associated with PGD. Persistent elevations in MCP-1 levels at 24 hours are a biomarker of grade 3 PGD post-transplantation. Monocyte chemotaxis may play a role in the pathogenesis of PGD."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.trsl.2012.08.003"xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/author | "Lee J.C."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/author | "Christie J.D."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/author | "Diamond J.M."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/author | "Kohl B."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/author | "Shah R.J."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/author | "Lederer D.J."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/author | "Ware L.B."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/author | "Sonett J."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/author | "Kawut S.M."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/author | "Arcasoy S.M."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/author | "Cantu E.M."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/author | "Demissie E.J."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/name | "Transl Res"xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/pages | "435-442"xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/title | "Plasma monocyte chemotactic protein-1 levels at 24 hours are a biomarker of primary graft dysfunction after lung transplantation."xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://purl.uniprot.org/core/volume | "160"xsd:string |
| http://purl.uniprot.org/citations/22989614 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22989614 |
| http://purl.uniprot.org/citations/22989614 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22989614 |
| http://purl.uniprot.org/uniprot/#_J3KRT7-mappedCitation-22989614 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22989614 |
| http://purl.uniprot.org/uniprot/#_P13500-mappedCitation-22989614 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22989614 |
| http://purl.uniprot.org/uniprot/#_Q6UZ82-mappedCitation-22989614 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22989614 |