| http://purl.uniprot.org/citations/22992737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22992737 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinases (MMPs) are extracellular zinc-dependent endopeptidases involved in the degradation and remodeling of extracellular matrix in physiological and pathological processes. MMPs also have a role in cell proliferation, migration, differentiation, angiogenesis, and apoptosis. We previously identified cancer invasion-related factors by comparing the gene expression profiles between parent and the highly invasive clone of cancer cells. Matrix metalloproteinase-13 (MMP-13) was identified as a common up-regulated gene by cancer invasion-related factors. Although MMP-13 slightly promoted tumor invasion, we found that MMP-13 was involved in tumor angiogenesis. Conditioned medium from MMP-13-overexpressing cells promoted capillary formation of immortalized human umbilical vein endothelial cells. Furthermore, treatment with recombinant MMP-13 protein enhanced capillary tube formation both in vitro and in vivo. MMP-13-promoted capillary tube formation was mediated by activation of focal adhesion kinase and ERK. Interestingly, MMP-13 promoted the secretion of VEGF-A from fibroblasts and endothelial cells. By immunohistochemical analysis, we found a possible correlation between MMP-13 expression and the number of blood vessels in human cancer cases. In summary, these findings suggest that MMP-13 may directly and indirectly promote tumor angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.373159"xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/author | "Kudo Y."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/author | "Yoshida M."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/author | "Kondo T."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/author | "Takata T."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/author | "Ishimaru N."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/author | "Tahara H."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/author | "Tsunematsu T."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/author | "Iizuka S."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/author | "Ogawa I."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/author | "Subarnbhesaj A."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/author | "Deraz E.M."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/author | "Siriwardena S.B."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/pages | "38716-38728"xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/title | "Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/22992737 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22992737 |
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| http://purl.uniprot.org/uniprot/#_A6JN28-mappedCitation-22992737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22992737 |
| http://purl.uniprot.org/uniprot/#_G3V742-mappedCitation-22992737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22992737 |