| http://purl.uniprot.org/citations/22992776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22992776 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of the present study was to explore the role of variations with modest effects (previously identified by a large-scale meta-analysis in European populations) in the genetic background of type 2 diabetes (T2D) and diabetes-related traits in a Japanese population. We enrolled 2632 Japanese subjects with T2D and 2050 non-diabetic subjects. We analyzed nine single-nucleotide polymorphisms (SNPs), including rs340874 (PROX1), rs4607517 (GCK), rs2191349 (DGKB-TMEM195), rs7034200 (GLIS3), rs10885122 (ADRA2A), rs174550 (FADS1), rs11605924 (CRY2), rs10830963 (MTNR1B) and rs35767 (IGF1). rs340874 (PROX1) and rs174550 (FADS1) were significantly associated with T2D (P=0.0078, OR: 1.12; and P=0.0071, OR: 1.12, respectively). Subjects with more risk alleles related to nine SNPs had an increased risk of T2D (P=0.0017), as well as a higher fasting plasma glucose level (P=0.018), higher HbA(1c) level (P=0.013) and lower HOMA-β (P=0.033) compared with subjects who had fewer risk alleles. We identified a significant association of a SNP of FADS1 and a SNP near PROX1 with T2D in a Japanese population. The present findings suggest that inclusion of SNPs with a tendency to increase the disease risk captured more of the genetic background of T2D than that revealed by only assessing significant SNPs."xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.org/dc/terms/identifier | "doi:10.1038/jhg.2012.110"xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/author | "Hara K."xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/author | "Fujita H."xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/author | "Kadowaki T."xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/author | "Iwata M."xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/author | "Seino S."xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/author | "Horikoshi M."xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/author | "Hirota Y."xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/author | "Tobe K."xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/author | "Shojima N."xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/name | "J Hum Genet"xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/pages | "776-779"xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/title | "Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits."xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/22992776 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22992776 |
| http://purl.uniprot.org/citations/22992776 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22992776 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MR51-mappedCitation-22992776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22992776 |
| http://purl.uniprot.org/uniprot/#_B4DP41-mappedCitation-22992776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22992776 |
| http://purl.uniprot.org/uniprot/#_B7Z5F3-mappedCitation-22992776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22992776 |
| http://purl.uniprot.org/uniprot/#_I3ZNE2-mappedCitation-22992776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22992776 |
| http://purl.uniprot.org/uniprot/#_I3ZNE3-mappedCitation-22992776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22992776 |
| http://purl.uniprot.org/uniprot/#_I3ZNH3-mappedCitation-22992776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22992776 |