| http://purl.uniprot.org/citations/22993212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22993212 | http://www.w3.org/2000/01/rdf-schema#comment | "Clathrin coat accessory proteins play key roles in transport mediated by clathrin-coated vesicles. Yeast Irc6p and the related mammalian p34 are putative clathrin accessory proteins that interact with clathrin adaptor complexes. We present evidence that Irc6p functions in clathrin-mediated traffic between the trans-Golgi network and endosomes, linking clathrin adaptor complex AP-1 and the Rab GTPase Ypt31p. The crystal structure of the Irc6p N-terminal domain revealed a G-protein fold most related to small G proteins of the Rab and Arf families. However, Irc6p lacks G-protein signature motifs and high-affinity GTP binding. Also, mutant Irc6p lacking candidate GTP-binding residues retained function. Mammalian p34 rescued growth defects in irc6 cells, indicating functional conservation, and modeling predicted a similar N-terminal fold in p34. Irc6p and p34 also contain functionally conserved C-terminal regions. Irc6p/p34-related proteins with the same two-part architecture are encoded in genomes of species as diverse as plants and humans. Together these results define Irc6p/p34 as a novel type of conserved clathrin accessory protein and founding members of a new G protein-like family."xsd:string |
| http://purl.uniprot.org/citations/22993212 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e12-07-0507"xsd:string |
| http://purl.uniprot.org/citations/22993212 | http://purl.uniprot.org/core/author | "Cascio D."xsd:string |
| http://purl.uniprot.org/citations/22993212 | http://purl.uniprot.org/core/author | "Lorenz T.C."xsd:string |
| http://purl.uniprot.org/citations/22993212 | http://purl.uniprot.org/core/author | "Payne G.S."xsd:string |
| http://purl.uniprot.org/citations/22993212 | http://purl.uniprot.org/core/author | "Costaguta G."xsd:string |
| http://purl.uniprot.org/citations/22993212 | http://purl.uniprot.org/core/author | "Daboussi L."xsd:string |
| http://purl.uniprot.org/citations/22993212 | http://purl.uniprot.org/core/author | "Gorynia S."xsd:string |
| http://purl.uniprot.org/citations/22993212 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22993212 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/22993212 | http://purl.uniprot.org/core/pages | "4416-4429"xsd:string |
| http://purl.uniprot.org/citations/22993212 | http://purl.uniprot.org/core/title | "Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins."xsd:string |
| http://purl.uniprot.org/citations/22993212 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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