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Background

The primary risk factor for chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC) is cigarette smoking but shared susceptibility factors, such as variations in the matrix metalloproteinase-1 (MMP1) gene, may also underlie both diseases.

Materials and methods

Cases with prevalent COPD (n=167), incident NSCLC (n=242), or prevalent COPD plus incident NSCLC (n=128) were compared to disease-free controls (n=338) to assess six MMP1 polymorphisms. The association between these polymorphisms and survival in NSCLC was also evaluated.

Results

Rs11292517 among African-Americans [odds ratio (OR)=5.48, 95% confidence interval (CI)=1.17-25.72] and rs2071230 among Caucasians (OR=2.51, 95% CI=1.09-5.77) appeared to be associated with NSCLC risk in the presence of COPD. Rs470558 appeared to be associated with survival in NSCLC among African-Americans (hazard ratio=3.94; 95%CI=1.14-13.63). No associations remained after adjusting for multiple comparisons.

Conclusion

Polymorphisms in MMP1 were not consistently associated with prevalent COPD or incident NSCLC nor with survival in NSCLC."xsd:string
http://purl.uniprot.org/citations/22993337http://purl.uniprot.org/core/author"Alberg A.J."xsd:string
http://purl.uniprot.org/citations/22993337http://purl.uniprot.org/core/author"Bowman E.D."xsd:string
http://purl.uniprot.org/citations/22993337http://purl.uniprot.org/core/author"Platz E.A."xsd:string
http://purl.uniprot.org/citations/22993337http://purl.uniprot.org/core/author"Enewold L."xsd:string
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http://purl.uniprot.org/citations/22993337http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22993337http://purl.uniprot.org/core/name"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/22993337http://purl.uniprot.org/core/pages"3917-3922"xsd:string
http://purl.uniprot.org/citations/22993337http://purl.uniprot.org/core/title"Association of matrix metalloproteinase-1 polymorphisms with risk of COPD and lung cancer and survival in lung cancer."xsd:string
http://purl.uniprot.org/citations/22993337http://purl.uniprot.org/core/volume"32"xsd:string
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