| http://purl.uniprot.org/citations/22994588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22994588 | http://www.w3.org/2000/01/rdf-schema#comment | "Localization of messenger RNA (mRNAs) contributes to generation and maintenance of cellular asymmetry, embryonic development and neuronal function. The She1-3 protein machinery in Saccharomyces cerevisiae localizes >30 mRNAs to the bud tip, including 13 mRNAs encoding membrane or secreted proteins. Ribonucleoprotein (RNP) particles can co-localize with tubular endoplasmic reticulum (ER) structures that form the initial elements for segregation of cortical ER (cER), suggesting a coordination of mRNA localization and cER distribution. By investigating localization of MS2-tagged mRNAs in yeast defective at various stages of cER segregation, we demonstrate that proper cER segregation is required for localization of only a subset of mRNAs. These mRNAs include WSC2, IST2, EAR1 and SRL1 that encode membrane or ER associated proteins and are expressed during S and G2 phases of the cell cycle when tubular ER movement into the bud occurs. Translation of WSC2 is not required for localization, ruling out co-translational targeting of this mRNA. Localization of ASH1 mRNA is independent of cER segregation, which is consistent with the expression pattern of ASH1 at late mitosis. Our findings indicate the presence of two different pathways to localize mRNAs to the yeast bud."xsd:string |
| http://purl.uniprot.org/citations/22994588 | http://purl.org/dc/terms/identifier | "doi:10.1111/tra.12011"xsd:string |
| http://purl.uniprot.org/citations/22994588 | http://purl.uniprot.org/core/author | "Jansen R.P."xsd:string |
| http://purl.uniprot.org/citations/22994588 | http://purl.uniprot.org/core/author | "Hermesh O."xsd:string |
| http://purl.uniprot.org/citations/22994588 | http://purl.uniprot.org/core/author | "Fundakowski J."xsd:string |
| http://purl.uniprot.org/citations/22994588 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22994588 | http://purl.uniprot.org/core/name | "Traffic"xsd:string |
| http://purl.uniprot.org/citations/22994588 | http://purl.uniprot.org/core/pages | "1642-1652"xsd:string |
| http://purl.uniprot.org/citations/22994588 | http://purl.uniprot.org/core/title | "Localization of a subset of yeast mRNAs depends on inheritance of endoplasmic reticulum."xsd:string |
| http://purl.uniprot.org/citations/22994588 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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