| http://purl.uniprot.org/citations/22994654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22994654 | http://www.w3.org/2000/01/rdf-schema#comment | "Prior studies have demonstrated associations between beta-adrenergic receptor (βAR) polymorphisms and left ventricular dysfunction-an important cause of allograft nonutilization for transplantation. We hypothesized that βAR polymorphisms predispose donor hearts to LV dysfunction after brain death. A total of 1043 organ donors managed from 2001-2006 were initially studied. The following βAR single nucleotide polymorphisms were genotyped: β1AR 1165C/G (Arg389Gly), β1AR 145A/G (Ser49Gly), β2AR 46G/A (Gly16Arg) and β2AR 79C/G (Gln27Glu). In multivariable regression analyses, the β2AR46 SNP was significantly associated with LV systolic dysfunction, with each minor allele additively decreasing the odds for LV ejection fraction <50%. The β1AR1165 and β2AR46 SNPs were associated with higher dopamine requirement during the donor management period: donors with the GG and AA genotypes had ORs of 2.64 (95% CI 1.52-4.57) and 2.70 (1.07-2.74) respectively for requiring >10 μg/kg/min of dopamine compared to those with the CC and GG genotypes. However, no significant associations were found between βAR SNPs and cardiac dysfunction in 364 donors managed from 2007-2008, perhaps due to changes in donor management, lack of power in this validation cohort, or the absence of a true association. βAR polymorphisms may be associated with cardiac dysfunction after brain death, but these relationships require further study in independent donor cohorts."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-6143.2012.04266.x"xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Nguyen J."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Young W.L."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Kwok P.Y."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Pawlikowska L."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Zaroff J.G."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Matthay M.A."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Baxter-Lowe L.A."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Poon A."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Goldstein B.A."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Sapru A."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Hayden V."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Khush K.K."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/author | "Menza R.L."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/name | "Am J Transplant"xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/pages | "3377-3386"xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/title | "Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors."xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/22994654 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22994654 |
| http://purl.uniprot.org/citations/22994654 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22994654 |
| http://purl.uniprot.org/uniprot/#_A2N4T7-mappedCitation-22994654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22994654 |