| http://purl.uniprot.org/citations/22999819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22999819 | http://www.w3.org/2000/01/rdf-schema#comment | "microRNAs (miRNAs) play important role in regulating cancer stem cell self-renewal and differentiation, but the expression prolife of miRNAs in glioma stem cells (GSCs) has not been addressed. Here, we found that CD133 positive GSCs possess a unique miRNAs profile compared to CD133 negative glioblastoma cells. miR-125b, as one of neuronal miRNAs, is the most significantly down-regulated miRNAs and overexpression of miR-125b inhibits the proliferation of CD133 positive GSCs and reduces the expression of "stem" marker. Furthermore, two binding sites for miR-125b are identified in the 3'UTR of E2F2 and overexpression of miR-125b in CD133 positive GSCs represses the endogenous level of E2F2 protein. This study demonstrated that miR-125b plays important roles in regulating the proliferation of GSCs by directly targeting E2F2."xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.08.023"xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://purl.uniprot.org/core/author | "Cao S."xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://purl.uniprot.org/core/author | "Wu N."xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://purl.uniprot.org/core/author | "Xiao L."xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22999819 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://purl.uniprot.org/core/pages | "3831-3839"xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://purl.uniprot.org/core/title | "miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2."xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://purl.uniprot.org/core/volume | "586"xsd:string |
| http://purl.uniprot.org/citations/22999819 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22999819 |
| http://purl.uniprot.org/citations/22999819 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22999819 |
| http://purl.uniprot.org/uniprot/#_Q14209-mappedCitation-22999819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22999819 |
| http://purl.uniprot.org/uniprot/#_Q5U0J0-mappedCitation-22999819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22999819 |
| http://purl.uniprot.org/uniprot/#_Q96ID7-mappedCitation-22999819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22999819 |
| http://purl.uniprot.org/uniprot/Q14209 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22999819 |
| http://purl.uniprot.org/uniprot/Q96ID7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22999819 |
| http://purl.uniprot.org/uniprot/Q5U0J0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22999819 |