| http://purl.uniprot.org/citations/22999926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22999926 | http://www.w3.org/2000/01/rdf-schema#comment | "Intracerebral hemorrhage (ICH), accounting for 15-20% of strokes, can cause significant brain injury and life long neurological deficits. We investigated whether treadmill exercise rehabilitation could improve brain repair after ICH and whether involvement of NFG-TrkA and BDNF-TrkB signaling could be observed during repair period in an experimental mouse ICH model reproduced by heparinized-collagenase infusion into the left caudate putamen. 5-Bromo-2-deoxyuridine (BrdU) labeled new dividing cell can be observed clearly around the injured cortex and striatum region on day 7 (D7) after operation, and both TrkA and TrkB neurotropic receptors were activated. A subgroup of these ICH mice began the treadmill exercise from D4 after operation. Then we found that the overall immunofluorescent signals of p-Y490-TrkA and p-Y705-TrkB were both decreased in all groups at D14 after operation. However, compared to the non-exercise ICH group mouse, the immunofluorescent intensity of BDNF and p-Y705-TrkB were significantly higher in the exercise group. In addition, there was no difference in p-Y490-TrkA. Our results suggest that BDNF-TrkB but not NGF-TrkA signaling is involved in the brain repair after ICH, and early proper treadmill exercise might promote this repair process."xsd:string |
| http://purl.uniprot.org/citations/22999926 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neulet.2012.09.021"xsd:string |
| http://purl.uniprot.org/citations/22999926 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/22999926 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/22999926 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/22999926 | http://purl.uniprot.org/core/author | "Qin J."xsd:string |
| http://purl.uniprot.org/citations/22999926 | http://purl.uniprot.org/core/author | "Su Q."xsd:string |
| http://purl.uniprot.org/citations/22999926 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22999926 | http://purl.uniprot.org/core/name | "Neurosci Lett"xsd:string |
| http://purl.uniprot.org/citations/22999926 | http://purl.uniprot.org/core/pages | "28-32"xsd:string |
| http://purl.uniprot.org/citations/22999926 | http://purl.uniprot.org/core/title | "Treadmill rehabilitation treatment enhanced BDNF-TrkB but not NGF-TrkA signaling in a mouse intracerebral hemorrhage model."xsd:string |
| http://purl.uniprot.org/citations/22999926 | http://purl.uniprot.org/core/volume | "529"xsd:string |
| http://purl.uniprot.org/citations/22999926 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22999926 |
| http://purl.uniprot.org/citations/22999926 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22999926 |
| http://purl.uniprot.org/uniprot/#_A0A286YDA3-mappedCitation-22999926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22999926 |
| http://purl.uniprot.org/uniprot/#_A0A1B4Z9M7-mappedCitation-22999926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22999926 |
| http://purl.uniprot.org/uniprot/#_B5BQV3-mappedCitation-22999926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22999926 |
| http://purl.uniprot.org/uniprot/#_B5BQV4-mappedCitation-22999926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22999926 |
| http://purl.uniprot.org/uniprot/#_E2IUB1-mappedCitation-22999926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22999926 |
| http://purl.uniprot.org/uniprot/#_Q3UHE3-mappedCitation-22999926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22999926 |
| http://purl.uniprot.org/uniprot/#_P01139-mappedCitation-22999926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22999926 |
| http://purl.uniprot.org/uniprot/#_P15209-mappedCitation-22999926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22999926 |
| http://purl.uniprot.org/uniprot/#_P21237-mappedCitation-22999926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22999926 |
| http://purl.uniprot.org/uniprot/#_Q3UFB7-mappedCitation-22999926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22999926 |