| http://purl.uniprot.org/citations/23000175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23000175 | http://www.w3.org/2000/01/rdf-schema#comment | "Trp63, a transcription factor related to the tumor suppressor p53, is activated by diverse stimuli and can initiate a range of cellular responses. TAp63 is the predominant Trp53 family member in primordial follicle oocyte nuclei and is essential for their apoptosis triggered by DNA damage in vivo. After γ-irradiation, induction of the proapoptotic BH3-only members Puma and Noxa was observed in primordial follicle oocytes from WT and Trp53(-/-) mice but not in those from TAp63-deficient mice. Primordial follicle oocytes from mice lacking Puma or both Puma and Noxa were protected from γ-irradiation-induced apoptosis and, remarkably, could produce healthy offspring. Hence, PUMA and NOXA are critical for DNA damage-induced, TAp63-mediated primordial follicle oocyte apoptosis. Thus, blockade of PUMA may protect fertility during cancer therapy and prevent premature menopause, improving women's health."xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.08.017"xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/author | "Bouillet P."xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/author | "Michalak E.M."xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/author | "Strasser A."xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/author | "Cook M."xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/author | "Vandenberg C.J."xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/author | "Scott C.L."xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/author | "Mills A."xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/author | "Findlay J.K."xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/author | "Hutt K.J."xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/author | "Kerr J.B."xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/author | "Liew S.H."xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/pages | "343-352"xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/title | "DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa."xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://purl.uniprot.org/core/volume | "48"xsd:string |
| http://purl.uniprot.org/citations/23000175 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23000175 |
| http://purl.uniprot.org/citations/23000175 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23000175 |
| http://purl.uniprot.org/uniprot/#_D3Z7K2-mappedCitation-23000175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23000175 |
| http://purl.uniprot.org/uniprot/#_D3Z2M5-mappedCitation-23000175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23000175 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GR88-mappedCitation-23000175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23000175 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1K8-mappedCitation-23000175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23000175 |