| http://purl.uniprot.org/citations/23000344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23000344 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we studied the cellular mechanisms of ursolic acid's anti-bladder cancer ability by focusing on endoplasmic reticulum stress (ER stress) signaling. We show that ursolic acid induces a significant ER stress response in cultured human bladder cancer T24 cells. ER stress inhibitor salubrinal, or PERK silencing, diminishes ursolic acid-induced anti-T24 cell effects. Salubrinal inhibits ursolic acid-induced CHOP expression, Bim ER accumulation and caspase-3 activation in T24 cells. Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. We suggest that ER stress contributes to ursolic acid's effects against bladder cancer cells."xsd:string |
| http://purl.uniprot.org/citations/23000344 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2012.09.012"xsd:string |
| http://purl.uniprot.org/citations/23000344 | http://purl.uniprot.org/core/author | "Zheng Q.Y."xsd:string |
| http://purl.uniprot.org/citations/23000344 | http://purl.uniprot.org/core/author | "Yao C."xsd:string |
| http://purl.uniprot.org/citations/23000344 | http://purl.uniprot.org/core/author | "Zhang G.H."xsd:string |
| http://purl.uniprot.org/citations/23000344 | http://purl.uniprot.org/core/author | "Ai X."xsd:string |
| http://purl.uniprot.org/citations/23000344 | http://purl.uniprot.org/core/author | "Li P.P."xsd:string |
| http://purl.uniprot.org/citations/23000344 | http://purl.uniprot.org/core/author | "Zang T."xsd:string |
| http://purl.uniprot.org/citations/23000344 | http://purl.uniprot.org/core/author | "Jin F.S."xsd:string |
| http://purl.uniprot.org/citations/23000344 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23000344 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/23000344 | http://purl.uniprot.org/core/pages | "206-213"xsd:string |
| http://purl.uniprot.org/citations/23000344 | http://purl.uniprot.org/core/title | "Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells."xsd:string |
| http://purl.uniprot.org/citations/23000344 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/23000344 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23000344 |
| http://purl.uniprot.org/citations/23000344 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23000344 |
| http://purl.uniprot.org/uniprot/Q9NZJ5#attribution-88D41C29DE8F9B6B67D41482FCEF3A98 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23000344 |
| http://purl.uniprot.org/uniprot/O75460#attribution-ABD8A087FABE0CAEB6333CE838EB4D88 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23000344 |
| http://purl.uniprot.org/uniprot/Q99683#attribution-88D41C29DE8F9B6B67D41482FCEF3A98 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23000344 |
| http://purl.uniprot.org/uniprot/Q99683#attribution-ABD8A087FABE0CAEB6333CE838EB4D88 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23000344 |
| http://purl.uniprot.org/uniprot/Q12933#attribution-ABD8A087FABE0CAEB6333CE838EB4D88 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23000344 |