| http://purl.uniprot.org/citations/23000418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23000418 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclooxygenase (COX)-derived prostaglandins and cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids are important regulators of inflammation; however, functional interactions between these pathways in the regulation of vascular inflammation in vivo have not been studied. We investigated the relative and additive effects of endothelial CYP2J2 overexpression (Tie2-CYP2J2-Tr), global sEH disruption (Ephx2(-/-)), and pharmacologic COX inhibition with indomethacin on the acute vascular inflammatory response to endotoxin in mice. Compared to vehicle-treated wild-type C57BL/6 controls, induction of myeloperoxidase (MPO) activity in lung and liver was similarly attenuated in Tie2-CYP2J2-Tr mice, Ephx2(-/-) mice and wild-type mice treated with moderate dose indomethacin. Dual modulation of both pathways, however, did not produce an additive anti-inflammatory effect. These findings demonstrate that both COX and CYP epoxygenase-mediated eicosanoid metabolism are important regulators of the acute vascular inflammatory response in vivo, and suggest that the anti-inflammatory effects of modulating each pathway may be mediated, at least in part, by overlapping mechanisms."xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.prostaglandins.2012.09.003"xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/author | "Deng Y."xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/author | "Lee C.R."xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/author | "Edin M.L."xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/author | "Lih F.B."xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/author | "Zeldin D.C."xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/author | "Tomer K.B."xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/author | "Molnar K."xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/author | "Theken K.N."xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/author | "Oni-Orisan A."xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/author | "Schuck R.N."xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/author | "DeGraff L."xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/name | "Prostaglandins Other Lipid Mediat"xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/pages | "67-73"xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/title | "Dual modulation of cyclooxygenase and CYP epoxygenase metabolism and acute vascular inflammation in mice."xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://purl.uniprot.org/core/volume | "104-105"xsd:string |
| http://purl.uniprot.org/citations/23000418 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23000418 |
| http://purl.uniprot.org/citations/23000418 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23000418 |
| http://purl.uniprot.org/uniprot/#_A8JYK8-mappedCitation-23000418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23000418 |
| http://purl.uniprot.org/uniprot/#_Q3UQ71-mappedCitation-23000418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23000418 |
| http://purl.uniprot.org/uniprot/#_P34914-mappedCitation-23000418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23000418 |
| http://purl.uniprot.org/uniprot/A8JYK8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23000418 |