| http://purl.uniprot.org/citations/23001182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23001182 | http://www.w3.org/2000/01/rdf-schema#comment | "We found that hematopoietic cell-specific Lyn substrate 1 (HCLS1 or HS1) is highly expressed in human myeloid cells and that stimulation with granulocyte colony-stimulating factor (G-CSF) leads to HCLS1 phosphorylation. HCLS1 binds the transcription factor lymphoid-enhancer binding factor 1 (LEF-1), transporting LEF-1 into the nucleus upon G-CSF stimulation and inducing LEF-1 autoregulation. In patients with severe congenital neutropenia, inherited mutations in the gene encoding HCLS1-associated protein X-1 (HAX1) lead to profound defects in G-CSF-triggered phosphorylation of HCLS1 and subsequently to reduced autoregulation and expression of LEF-1. Consistent with these results, HCLS1-deficient mice are neutropenic. In bone marrow biopsies of the majority of tested patients with acute myeloid leukemia, HCLS1 protein expression is substantially elevated, associated with high levels of G-CSF synthesis and, in some individuals, a four-residue insertion in a proline-rich region of HCLS1 protein known to accelerate intracellular signaling. These data demonstrate the importance of HCLS1 in myelopoiesis in vitro and in vivo."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.2958"xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Gupta K."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Lan D."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Grosschedl R."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Hussein K."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Welte K."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Klimenkova O."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Klimiankou M."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Skokowa J."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Zeidler C."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Ganser A."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Kreipe H.H."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Carrizosa E."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Burkhardt J."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Sustmann C."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/author | "Kusnetsova I."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/pages | "1550-1559"xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/title | "Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis."xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/23001182 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23001182 |