| http://purl.uniprot.org/citations/23007648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23007648 | http://www.w3.org/2000/01/rdf-schema#comment | "The spindle assembly checkpoint (SAC) is essential to ensure proper chromosome segregation and thereby maintain genomic stability. The SAC monitors chromosome attachment, and any unattached chromosomes generate a "wait anaphase" signal that blocks chromosome segregation. The target of the SAC is Cdc20, which activates the anaphase-promoting complex/cyclosome (APC/C) that triggers anaphase and mitotic exit by ubiquitylating securin and cyclin B1. The inhibitory complex formed by the SAC has recently been shown to inhibit Cdc20 by acting as a pseudosubstrate inhibitor, but in this paper, we show that Mad2 also inhibits Cdc20 by binding directly to a site required to bind the APC/C. Mad2 and the APC/C competed for Cdc20 in vitro, and a Cdc20 mutant that does not bind stably to Mad2 abrogated the SAC in vivo. Thus, we provide insights into how Cdc20 binds the APC/C and uncover a second mechanism by which the SAC inhibits the APC/C."xsd:string |
| http://purl.uniprot.org/citations/23007648 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201205170"xsd:string |
| http://purl.uniprot.org/citations/23007648 | http://purl.uniprot.org/core/author | "Pines J."xsd:string |
| http://purl.uniprot.org/citations/23007648 | http://purl.uniprot.org/core/author | "Izawa D."xsd:string |
| http://purl.uniprot.org/citations/23007648 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23007648 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23007648 | http://purl.uniprot.org/core/pages | "27-37"xsd:string |
| http://purl.uniprot.org/citations/23007648 | http://purl.uniprot.org/core/title | "Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation."xsd:string |
| http://purl.uniprot.org/citations/23007648 | http://purl.uniprot.org/core/volume | "199"xsd:string |
| http://purl.uniprot.org/citations/23007648 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23007648 |
| http://purl.uniprot.org/citations/23007648 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23007648 |
| http://purl.uniprot.org/uniprot/#_Q13257-mappedCitation-23007648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23007648 |
| http://purl.uniprot.org/uniprot/Q13257 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23007648 |