| http://purl.uniprot.org/citations/23007861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23007861 | http://www.w3.org/2000/01/rdf-schema#comment | "The anaphase-promoting complex/cyclosome (APC/C) bound to CDC20 (APC/C(CDC20)) initiates anaphase by ubiquitylating B-type cyclins and securin. During chromosome bi-orientation, CDC20 assembles with MAD2, BUBR1 and BUB3 into a mitotic checkpoint complex (MCC) that inhibits substrate recruitment to the APC/C. APC/C activation depends on MCC disassembly, which was proposed to require CDC20 autoubiquitylation. Here we characterize APC15, a human APC/C subunit related to yeast Mnd2. APC15 is located near APC/C's MCC binding site; it is required for APC/C-bound MCC (APC/C(MCC))-dependent CDC20 autoubiquitylation and degradation and for timely anaphase initiation but is dispensable for substrate ubiquitylation by APC/C(CDC20) and APC/C(CDH1). Our results support the model wherein MCC is continuously assembled and disassembled to enable rapid activation of APC/C(CDC20) and CDC20 autoubiquitylation promotes MCC disassembly. We propose that APC15 and Mnd2 negatively regulate APC/C coactivators and report generation of recombinant human APC/C."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2412"xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Hyman A.A."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Toyoda Y."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Stark H."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Peters J.M."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Schulman B.A."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Petzold G."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Mechtler K."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Jarvis M.A."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Novatchkova M."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Brown N.G."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Poser I."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Ladurner R."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Dye B.T."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Uzunova K."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/author | "Schutz H."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/pages | "1116-1123"xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/title | "APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex."xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/23007861 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23007861 |
| http://purl.uniprot.org/citations/23007861 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23007861 |