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http://purl.uniprot.org/citations/23010268http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23010268http://www.w3.org/2000/01/rdf-schema#comment"A set of low molecular weight compounds containing a hydroxyethylamine (HEA) core structure with different prime side alkyl substituted 4,5,6,7-tetrahydrobenzazoles and one 4,5,6,7-tetrahydropyridinoazole was synthesized. Striking differences were observed on potencies in the BACE-1 enzymatic and cellular assays depending on the nature of the heteroatoms in the bicyclic ring, from the low active compound 4 to inhibitor 6, displaying BACE-1 IC(50) values of 44 nM (enzyme assay) and 65 nM (cell-based assay)."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.org/dc/terms/identifier"doi:10.1016/j.bmcl.2012.08.097"xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/author"Lindberg J."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/author"Vrang L."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/author"Borkakoti N."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/author"Wikstrom K."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/author"Woestenenk E."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/author"Lindstrom E."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/author"Derbyshire D."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/author"Belda O."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/author"Eneroth A."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/author"Hamelink E."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/author"Sund C."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/author"Ahgren C."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/author"Kalayanov G."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/name"Bioorg Med Chem Lett"xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/pages"6721-6727"xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/title"Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates."xsd:string
http://purl.uniprot.org/citations/23010268http://purl.uniprot.org/core/volume"22"xsd:string
http://purl.uniprot.org/citations/23010268http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23010268
http://purl.uniprot.org/citations/23010268http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23010268
http://purl.uniprot.org/uniprot/#_P56817-mappedCitation-23010268http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23010268
http://purl.uniprot.org/uniprot/P56817http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/23010268