http://purl.uniprot.org/citations/23010268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/23010268 | http://www.w3.org/2000/01/rdf-schema#comment | "A set of low molecular weight compounds containing a hydroxyethylamine (HEA) core structure with different prime side alkyl substituted 4,5,6,7-tetrahydrobenzazoles and one 4,5,6,7-tetrahydropyridinoazole was synthesized. Striking differences were observed on potencies in the BACE-1 enzymatic and cellular assays depending on the nature of the heteroatoms in the bicyclic ring, from the low active compound 4 to inhibitor 6, displaying BACE-1 IC(50) values of 44 nM (enzyme assay) and 65 nM (cell-based assay)."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bmcl.2012.08.097"xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/author | "Lindberg J."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/author | "Vrang L."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/author | "Borkakoti N."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/author | "Wikstrom K."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/author | "Woestenenk E."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/author | "Lindstrom E."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/author | "Derbyshire D."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/author | "Belda O."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/author | "Eneroth A."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/author | "Hamelink E."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/author | "Sund C."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/author | "Ahgren C."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/author | "Kalayanov G."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/name | "Bioorg Med Chem Lett"xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/pages | "6721-6727"xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/title | "Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates."xsd:string |
http://purl.uniprot.org/citations/23010268 | http://purl.uniprot.org/core/volume | "22"xsd:string |
http://purl.uniprot.org/citations/23010268 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23010268 |
http://purl.uniprot.org/citations/23010268 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23010268 |
http://purl.uniprot.org/uniprot/#_P56817-mappedCitation-23010268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23010268 |
http://purl.uniprot.org/uniprot/P56817 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23010268 |