| http://purl.uniprot.org/citations/23011134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23011134 | http://www.w3.org/2000/01/rdf-schema#comment | "Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the fragile X mental retardation protein, which regulates signal transduction at metabotropic glutamate receptor-5 in the brain. Fragile X mental retardation protein deletion in mice enhances metabotropic glutamate receptor-5-dependent long-term depression in the hippocampus and cerebellum. Here we show that a distinct type of metabotropic glutamate receptor-5-dependent long-term depression at excitatory synapses of the ventral striatum and prefrontal cortex, which is mediated by the endocannabinoid 2-arachidonoyl-sn-glycerol, is absent in fragile X mental retardation protein-null mice. In these mutants, the macromolecular complex that links metabotropic glutamate receptor-5 to the 2-arachidonoyl-sn-glycerol-producing enzyme, diacylglycerol lipase-α (endocannabinoid signalosome), is disrupted and metabotropic glutamate receptor-5-dependent 2-arachidonoyl-sn-glycerol formation is compromised. These changes are accompanied by impaired endocannabinoid-dependent long-term depression. Pharmacological enhancement of 2-arachidonoyl-sn-glycerol signalling normalizes this synaptic defect and corrects behavioural abnormalities in fragile X mental retardation protein-deficient mice. The results identify the endocannabinoid signalosome as a molecular substrate for fragile X syndrome, which might be targeted by therapy."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms2045"xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/author | "Martin H."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/author | "Mackie K."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/author | "Manzoni O.J."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/author | "Frick A."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/author | "Katona I."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/author | "Piomelli D."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/author | "Jung K.M."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/author | "Henstridge C.M."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/author | "Ginger M."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/author | "DiPatrizio N.V."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/author | "Lassalle O."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/author | "Neuhofer D."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/author | "Sepers M."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/pages | "1080"xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/title | "Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome."xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/23011134 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23011134 |
| http://purl.uniprot.org/citations/23011134 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23011134 |
| http://purl.uniprot.org/uniprot/Q6WQJ1#attribution-C395B90D40D6E1B44508B1D8DE923F18 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23011134 |
| http://purl.uniprot.org/uniprot/#_A4FU75-mappedCitation-23011134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23011134 |