| http://purl.uniprot.org/citations/23012327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23012327 | http://www.w3.org/2000/01/rdf-schema#comment | "Chemokines regulate the migration of hemopoietic cells and play an important role in the pathogenesis of many immune-mediated diseases. Intradermal recruitment of CD8(+) T cells by CXCL10 is a central feature of the pathogenesis of cutaneous acute GVHD (aGVHD), but very little is known about the pathogenesis of chronic GVHD (cGVHD). Serum concentrations of the 3 CXCR3-binding chemokines, CXCL9, CXCL10, and CXCL11, were found to be markedly increased in patients with active cGVHD of the skin (n = 8). An 80% decrease in CD4(+) cells expressing CXCR3 was seen in the blood of these patients (n = 5), whereas CD4(+) cells were increased in tissue biopsies and were clustered around the central arterioles of the dermis. The well-documented increase in expression of CXCL10 in aGVHD therefore diversifies in cGVHD to include additional members of the CXCR3-binding family and leads to preferential recruitment of CD4(+) T cells. These observations reveal a central role for chemokine-mediated recruitment of CXCR3(+) T cells in cGVHD."xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2012-02-413260"xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/author | "Craddock C."xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/author | "Malladi R."xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/author | "Moss P.A."xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/author | "Mahendra P."xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/author | "Abbotts B.E."xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/author | "Croudace J.E."xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/author | "Inman C.F."xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/author | "Nagra S."xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/author | "Nunnick J."xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/pages | "4246-4255"xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/title | "Chemokine-mediated tissue recruitment of CXCR3+ CD4+ T cells plays a major role in the pathogenesis of chronic GVHD."xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/23012327 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23012327 |
| http://purl.uniprot.org/citations/23012327 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23012327 |
| http://purl.uniprot.org/uniprot/#_B2R4J7-mappedCitation-23012327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23012327 |
| http://purl.uniprot.org/uniprot/#_O14625-mappedCitation-23012327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23012327 |
| http://purl.uniprot.org/uniprot/#_P02778-mappedCitation-23012327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23012327 |
| http://purl.uniprot.org/uniprot/#_Q07325-mappedCitation-23012327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23012327 |
| http://purl.uniprot.org/uniprot/#_Q96KF0-mappedCitation-23012327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23012327 |
| http://purl.uniprot.org/uniprot/P02778 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23012327 |