| http://purl.uniprot.org/citations/23012656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23012656 | http://www.w3.org/2000/01/rdf-schema#comment | "Schwann cells respond to cues from axons by transforming their cellular morphology and forming myelin. We demonstrated that the guanine nucleotide exchange factor (GEF) cytohesin-1 promoted myelination by activating the small guanosine triphosphatase (GTPase) Arf6. In mice, ablating cytohesin-1 delayed myelination and diminished the amount of myelin produced. We determined that the Src-family kinase Fyn phosphorylated tyrosine 382 (Y(382)) of cytohesin-1, and we generated transgenic mice that expressed a Schwann cell-specific phosphorylation mutant of cytohesin-1 (Y382F) that could not be targeted by Fyn. During development, these transgenic mice displayed delayed myelination compared to that of wild-type mice, as well as a decrease in the amount of myelin produced, similar to that observed in cytohesin-1⁻/⁻ mice. These findings demonstrate that phosphorylation of cytohesin-1 by Fyn is required for full myelination and suggest that tyrosine phosphorylation of GEFs may be a mechanism to activate small GTPases engaged in cell morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.2002802"xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/author | "Kondo K."xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/author | "Nemoto N."xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/author | "Miyamoto Y."xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/author | "Kawahara K."xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/author | "Takashima S."xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/author | "Tsujimoto G."xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/author | "Tanoue A."xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/author | "Torii T."xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/author | "Yamauchi J."xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/author | "Chan J.R."xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/pages | "ra69"xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/title | "Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development."xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/23012656 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23012656 |
| http://purl.uniprot.org/citations/23012656 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23012656 |
| http://purl.uniprot.org/uniprot/#_D3YVZ0-mappedCitation-23012656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23012656 |
| http://purl.uniprot.org/uniprot/#_D3YYY2-mappedCitation-23012656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23012656 |
| http://purl.uniprot.org/uniprot/#_D3YZ57-mappedCitation-23012656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23012656 |
| http://purl.uniprot.org/uniprot/#_D3YXS2-mappedCitation-23012656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23012656 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MPM4-mappedCitation-23012656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23012656 |