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http://purl.uniprot.org/citations/23013868http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23013868http://www.w3.org/2000/01/rdf-schema#comment"

Background

Axonopathy is critical in the early pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Axonal swellings such as globules and spheroids are a distinct feature of axonopathy and our recent study showed that transgenic (tg) mice expressing DLB-linked P123H β-synuclein (P123H βS) were characterized by P123H βS-immunoreactive axonal swellings (P123H βS-globules). Therefore, the objectives of this study were to evaluate α-synuclein (αS)-immunoreactive axonal swellings (αS-globules) in the brains of tg mice expressing human wild-type αS and to compare them with the globules in P123H βS tg mice.

Results

In αS tg mice, αS-globules were formed in an age-dependent manner in various brain regions, including the thalamus and basal ganglia. These globules were composed of autophagosome-like membranous structures and were reminiscent of P123H βS-globules in P123H βS tg mice. In the αS-globules, frequent clustering and deformation of mitochondria were observed. These changes were associated with oxidative stress, based on staining of nitrated αS and 4-hydroxy-2-nonenal (4-HNE). In accord with the absence of mitochondria in the P123H βS-globules, staining of nitrated αS and 4-HNE in these globules was weaker than that for αS-globules. Leucine-rich repeat kinase 2 (LRRK2), the PARK8 of familial PD, was detected exclusively in αS-globules, suggesting a specific role of this molecule in these globules.

Conclusions

Lysosomal pathology was similarly observed for both αS- and P123H βS-globules, while oxidative stress was associated with the αS-globules, and to a lesser extent with the P123H βS-globules. Other pathologies, such as mitochondrial alteration and LRRK2 accumulation, were exclusively detected for αS-globules. Collectively, both αS- and P123H βS-globules were formed through similar but distinct pathogenic mechanisms. Our findings suggest that synuclein family members might contribute to diverse axonal pathologies."xsd:string
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http://purl.uniprot.org/citations/23013868http://purl.uniprot.org/core/author"Fujita M."xsd:string
http://purl.uniprot.org/citations/23013868http://purl.uniprot.org/core/author"Hashimoto M."xsd:string
http://purl.uniprot.org/citations/23013868http://purl.uniprot.org/core/author"Masliah E."xsd:string
http://purl.uniprot.org/citations/23013868http://purl.uniprot.org/core/author"Hatano T."xsd:string
http://purl.uniprot.org/citations/23013868http://purl.uniprot.org/core/author"Takamatsu Y."xsd:string
http://purl.uniprot.org/citations/23013868http://purl.uniprot.org/core/author"La Spada A.R."xsd:string
http://purl.uniprot.org/citations/23013868http://purl.uniprot.org/core/author"Rockenstein E."xsd:string
http://purl.uniprot.org/citations/23013868http://purl.uniprot.org/core/author"Sekiyama K."xsd:string
http://purl.uniprot.org/citations/23013868http://purl.uniprot.org/core/author"Sekigawa A."xsd:string
http://purl.uniprot.org/citations/23013868http://purl.uniprot.org/core/date"2012"xsd:gYear
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http://purl.uniprot.org/citations/23013868http://purl.uniprot.org/core/pages"34"xsd:string
http://purl.uniprot.org/citations/23013868http://purl.uniprot.org/core/title"Distinct mechanisms of axonal globule formation in mice expressing human wild type alpha-synuclein or dementia with Lewy bodies-linked P123H beta-synuclein."xsd:string
http://purl.uniprot.org/citations/23013868http://purl.uniprot.org/core/volume"5"xsd:string
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