| http://purl.uniprot.org/citations/23019328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23019328 | http://www.w3.org/2000/01/rdf-schema#comment | "Sarcolemmal CD36 facilitates myocardial fatty acid (FA) uptake, which is markedly reduced in CD36-deficient rodents and humans. CD36 also mediates signal transduction events involving a number of cellular pathways. In taste cells and macrophages, CD36 signaling was recently shown to regulate store-responsive Ca(2+) flux and activation of Ca(2+)-dependent phospholipases A(2) that cycle polyunsaturated FA into phospholipids. It is unknown whether CD36 deficiency influences myocardial Ca(2+) handling and phospholipid metabolism, which could compromise the heart, typically during stresses. Myocardial function was examined in fed or fasted (18-22 h) CD36(-/-) and WT mice. Echocardiography and telemetry identified conduction anomalies that were associated with the incidence of sudden death in fasted CD36(-/-) mice. No anomalies or death occurred in WT mice during fasting. Optical imaging of perfused hearts from fasted CD36(-/-) mice documented prolongation of Ca(2+) transients. Consistent with this, knockdown of CD36 in cardiomyocytes delayed clearance of cytosolic Ca(2+). Hearts of CD36(-/-) mice (fed or fasted) had 3-fold higher SERCA2a and 40% lower phospholamban levels. Phospholamban phosphorylation by protein kinase A (PKA) was enhanced after fasting reflecting increased PKA activity and cAMP levels in CD36(-/-) hearts. Abnormal Ca(2+) homeostasis in the CD36(-/-) myocardium associated with increased lysophospholipid content and a higher proportion of 22:6 FA in phospholipids suggests altered phospholipase A(2) activity and changes in membrane dynamics. The data support the role of CD36 in coordinating Ca(2+) homeostasis and lipid metabolism and the importance of this role during myocardial adaptation to fasting. Potential relevance of the findings to CD36-deficient humans would need to be determined."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.413609"xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/author | "Gross R.W."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/author | "Yang K."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/author | "Su X."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/author | "Abumrad N.A."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/author | "Nerbonne J.M."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/author | "Efimov I.R."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/author | "Yamada K.A."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/author | "Kuda O."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/author | "Pietka T.A."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/author | "Sulkin M.S."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/pages | "38901-38912"xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/title | "CD36 protein influences myocardial Ca2+ homeostasis and phospholipid metabolism: conduction anomalies in CD36-deficient mice during fasting."xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/23019328 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23019328 |
| http://purl.uniprot.org/citations/23019328 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23019328 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFB7-mappedCitation-23019328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23019328 |
| http://purl.uniprot.org/uniprot/#_E7D893-mappedCitation-23019328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23019328 |
| http://purl.uniprot.org/uniprot/#_Q3U6Y9-mappedCitation-23019328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23019328 |