| http://purl.uniprot.org/citations/23019580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23019580 | http://www.w3.org/2000/01/rdf-schema#comment | "Appropriate expression of IL-2 plays a central role during the priming and differentiation of T cells. A tight balance between IL-2 and the effector cytokine IL-17A is essential for immune homeostasis. Epigenetic mechanisms have been documented as a key component of cytokine regulation during lineage commitment. The molecular mechanisms that induce chromatin remodeling are less well understood. We investigated epigenetic regulators that mediate the diametric expression of IL-2 and IL-17A in naive, central memory, and effector memory CD4(+) T cells. We demonstrate that cAMP response modulator (CREM)α contributes to epigenetic remodeling of IL2 in effector memory T cells through the recruitment of DNMT3a. CREMα also reduces CpG-DNA methylation of the IL17A promoter. CREMα expression is regulated at the epigenetic level by CpG-DNA methylation, which allows increased CREMα expression in effector memory CD4(+) T cells. T cells from patients with systemic lupus erythematosus (SLE) express increased levels of CREMα and exhibit a phenotype that is similar to effector memory CD4(+) T cells with epigenetically predetermined expression patterns of IL-2 and IL-17A. We conclude that CREMα mediates epigenetic remodeling of the IL2 and IL17A gene during T-cell differentiation in favor of effector memory T cells in health and disease."xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1210129109"xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://purl.uniprot.org/core/author | "Apostolidis S.A."xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://purl.uniprot.org/core/author | "Crispin J.C."xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://purl.uniprot.org/core/author | "Tsokos G.C."xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://purl.uniprot.org/core/author | "Lo M.S."xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://purl.uniprot.org/core/author | "Hedrich C.M."xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://purl.uniprot.org/core/author | "Ioannidis C."xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://purl.uniprot.org/core/author | "Kyttaris V.C."xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://purl.uniprot.org/core/author | "Rauen T."xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23019580 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://purl.uniprot.org/core/pages | "16606-16611"xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://purl.uniprot.org/core/title | "cAMP response element modulator alpha controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus."xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/23019580 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23019580 |
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| http://purl.uniprot.org/uniprot/#_D9MX03-mappedCitation-23019580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23019580 |
| http://purl.uniprot.org/uniprot/#_Q13169-mappedCitation-23019580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23019580 |
| http://purl.uniprot.org/uniprot/#_Q71V48-mappedCitation-23019580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23019580 |
| http://purl.uniprot.org/uniprot/#_Q5QEX9-mappedCitation-23019580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23019580 |
| http://purl.uniprot.org/uniprot/#_Q16552-mappedCitation-23019580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23019580 |
| http://purl.uniprot.org/uniprot/#_Q6QWN0-mappedCitation-23019580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23019580 |
| http://purl.uniprot.org/uniprot/#_Q16334-mappedCitation-23019580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23019580 |