| http://purl.uniprot.org/citations/23022409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23022409 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 6 (IL-6) is a pivotal cytokine that regulates extracellular matrix metabolism by ameliorating the modification of collagen content, important in fibrous caps of atherosclerotic plaque. Prolyl-4-hydroxylase α1 (P4Hα1) is a key intracellular enzyme required for synthesis of collagen in animals. We investigated the relationship of IL-6 and P4Hα1 in atherosclerosis-prone mice and human aortic smooth muscle cells (HASMCs). Apolipoprotein E (ApoE)-/-mice were fed a high-fat diet and a perivascular constrictive silica collar was placed on the right common carotid artery to induce atherosclerotic lesions, then mice were divided into two groups for transfection with empty lentivirus or IL-6 lentivirus. HASMCs were transfected with small interfering RNA or treated with recombinant human IL-6. IL-6 significantly downregulated collagen, P4Hα1 and smooth muscle cell contents in atherosclerotic mouse arteries. Macrophage and lipid contents in the atherosclerotic area were significantly increased with IL-6 treatment. IL-6 significantly downregulated P4Hα1 expression in HASMCs through an RAF-MEK1/2-ERK1/2 mitogen-activated protein kinase (MAPK) pathway, and c-Jun was involved in the process. Our findings highlight IL-6 destabilize atherosclerotic plaques in mice by downregulating P4Hα1 via an RAF-MEK1/2-ERK1/2 MAPK and c-Jun pathway."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.abb.2012.09.007"xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/author | "Zhang M.X."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/author | "Feng M."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/author | "Wang X.L."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/author | "Liu X.L."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/author | "Huang X.Z."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/author | "Li X.N."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/author | "Cai X.J."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/name | "Arch Biochem Biophys"xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/pages | "127-133"xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/title | "Interleukin 6 destabilizes atherosclerotic plaques by downregulating prolyl-4-hydroxylase alpha1 via a mitogen-activated protein kinase and c-Jun pathway."xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://purl.uniprot.org/core/volume | "528"xsd:string |
| http://purl.uniprot.org/citations/23022409 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23022409 |
| http://purl.uniprot.org/citations/23022409 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23022409 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-23022409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23022409 |
| http://purl.uniprot.org/uniprot/#_E9Q7B0-mappedCitation-23022409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23022409 |
| http://purl.uniprot.org/uniprot/#_Q0PMN1-mappedCitation-23022409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23022409 |