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| http://purl.uniprot.org/citations/23022559 | http://www.w3.org/2000/01/rdf-schema#comment | "The axon/dendrite specification collapsin response mediator protein-2 (CRMP-2) bidirectionally regulates N-type voltage-gated Ca(2+) channels (CaV2.2). But how cyclin dependent kinase 5 (Cdk5)-mediated phosphorylation of CRMP-2 affects its interaction/regulation with CaV2.2 is unknown. CRMP-2-mediated enhancement of currents via CaV2.2 was not observed with a Cdk5 phospho-null CRMP-2-S522A mutant or in cells expressing an inactive Cdk5. Concomitant knockdown of endogenous CRMP2 and overexpression of CRMP2-S522A mutant refractory to knockdown phenocopied the reduction in Ca(2+) influx while the Rho kinase CRMP2-T555A mutant was ineffective. Cdk5-phosphorylated CRMP-2 had increased association with CaV2.2. These results identify an important role for Cdk5 in CRMP2-mediated CaV2.2 regulation."xsd:string |
| http://purl.uniprot.org/citations/23022559 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.09.022"xsd:string |
| http://purl.uniprot.org/citations/23022559 | http://purl.uniprot.org/core/author | "Khanna R."xsd:string |
| http://purl.uniprot.org/citations/23022559 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/23022559 | http://purl.uniprot.org/core/author | "Brittain J.M."xsd:string |
| http://purl.uniprot.org/citations/23022559 | http://purl.uniprot.org/core/author | "Eruvwetere O."xsd:string |
| http://purl.uniprot.org/citations/23022559 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23022559 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/23022559 | http://purl.uniprot.org/core/pages | "3813-3818"xsd:string |
| http://purl.uniprot.org/citations/23022559 | http://purl.uniprot.org/core/title | "Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2."xsd:string |
| http://purl.uniprot.org/citations/23022559 | http://purl.uniprot.org/core/volume | "586"xsd:string |
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