| http://purl.uniprot.org/citations/23022728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23022728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23022728 | http://www.w3.org/2000/01/rdf-schema#comment | "Both epigenetic and splicing regulation contribute to tumor progression, but the potential links between these two levels of gene-expression regulation in pathogenesis are not well understood. Here, we report that the mouse and human RNA helicases Ddx17 and Ddx5 contribute to tumor-cell invasiveness by regulating alternative splicing of several DNA- and chromatin-binding factors, including the macroH2A1 histone. We show that macroH2A1 splicing isoforms differentially regulate the transcription of a set of genes involved in redox metabolism. In particular, the SOD3 gene that encodes the extracellular superoxide dismutase and plays a part in cell migration is regulated in an opposite manner by macroH2A1 splicing isoforms. These findings reveal a new regulatory pathway in which splicing factors control the expression of histone variant isoforms that in turn drive a transcription program to switch tumor cells to an invasive phenotype."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2390"xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2390"xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Dutertre M."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Dutertre M."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Germann S."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Germann S."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Lidereau R."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Lidereau R."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Vagner S."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Vagner S."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Auboeuf D."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Auboeuf D."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Dardenne E."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Dardenne E."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Driouch K."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Driouch K."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Espinoza M.P."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Espinoza M.P."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Gratadou L."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Gratadou L."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Lacroix-Triki M."xsd:string |
| http://purl.uniprot.org/citations/23022728 | http://purl.uniprot.org/core/author | "Lacroix-Triki M."xsd:string |