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http://purl.uniprot.org/citations/23022913http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23022913http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

Neuroinflammatory mechanisms are associated with fatigue in neurodegenerative conditions such as Parkinson's. The symptoms in Parkinson's including fatigue are thought to be related to α-synuclein overexpression. This study investigated genomic correlates of fatigue experienced by men with prostate cancer receiving external beam radiation therapy (EBRT).

Patients and methods

Sixteen men with non-metastatic prostate cancer who were scheduled to receive EBRT were enrolled. Fatigue scores and blood were obtained at baseline (prior to EBRT, D0); one hour following initiation of EBRT (D1), day 7 (D7), day 14 (D14), midpoint (days 19-21, D21), completion (days 38-42, D42), and four weeks post-EBRT (days 68-72, D72). Gene expression profiling using microarray analysis was performed from peripheral blood and confirmatory qPCR and protein (ELISA) analyses verified the microarray results. Correlations between fatigue and gene/protein expressions were determined using a mixed model approach.

Results

Microarray data showed significant, differential expression of 463 probesets following EBRT. SNCA had a 2.95-fold change at D21 from baseline. SNCA expression was confirmed by qPCR (p<0.001) and ELISA (p<0.001) over time during EBRT. Fatigue scores were significantly correlated with SNCA gene expression on D14 (r=0.55, p<0.05) and plasma α-synuclein concentrations on D42 of EBRT (r=0.54, p=0.04).

Conclusion

Fatigue experienced during EBRT may be mediated by α-synuclein overexpression. Alpha-synuclein may serve as a useful biomarker to understand the mechanisms and pathways related to the development of fatigue in this population."xsd:string
http://purl.uniprot.org/citations/23022913http://purl.org/dc/terms/identifier"doi:10.1016/j.bbi.2012.09.009"xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/author"Wang D."xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/author"Wang X.M."xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/author"Munson P.J."xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/author"Kaushal A."xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/author"Barb J.J."xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/author"St John L."xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/author"Dionne R.A."xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/author"Citrin D."xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/author"Hsiao C.P."xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/author"Saligan L.N."xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/name"Brain Behav Immun"xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/pages"63-70"xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/title"Upregulation of alpha-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways."xsd:string
http://purl.uniprot.org/citations/23022913http://purl.uniprot.org/core/volume"27"xsd:string
http://purl.uniprot.org/citations/23022913http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23022913
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