DESCRIBE <http://purl.uniprot.org/citations/23027442>

Subject	Predicate	Object
http://purl.uniprot.org/citations/23027442	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23027442	http://www.w3.org/2000/01/rdf-schema#comment	" Background The podocyte slit diaphragm (SD) is an essential component of the selective filtration barrier in the glomerulus. Several structural proteins required for formation and maintenance of SD have been identified; however, molecular mechanisms regulating these proteins are still limited. Results Here, we demonstrate that MAGUK p55 subfamily member 5a (Mpp5a)/Nagie oko, a component of the Crb multi-protein complex, was colocalized with an SD-associated protein ZO-1 in the zebrafish pronephric glomerulus. To characterize the function of Mpp5a, zebrafish mpp5a(m520) mutant embryos, which are known to have defects in cardiac and neuronal morphogenesis, were analyzed. These mutants failed to merge the bilateral glomerular primordia and to form the glomerular capillary and mesangium, but the foot processes and SD showed normal appearance. The structural disorganization in the mpp5a(m520) mutant glomerulus was quite similar to that of a cardiac troponin T2a/tnnt2a/silent heart knockdown zebrafish, which exhibited circulatory failure due to lack of heart beating. Conclusions Mpp5a is not prerequisite to form podocyte slit diaphragm in the pronephric glomerular development in zebrafish. The structural disorganization of the pronephric glomerulus in the mpp5a(m520) mutant is likely to result from circulatory failure, rather than the anomaly of Mpp5a protein in the glomerulus."xsd:string
http://purl.uniprot.org/citations/23027442	http://purl.org/dc/terms/identifier	"doi:10.1002/dvdy.23877"xsd:string
http://purl.uniprot.org/citations/23027442	http://purl.uniprot.org/core/author	"Nakamura T."xsd:string
http://purl.uniprot.org/citations/23027442	http://purl.uniprot.org/core/author	"Sakai T."xsd:string
http://purl.uniprot.org/citations/23027442	http://purl.uniprot.org/core/author	"Ichimura K."xsd:string
http://purl.uniprot.org/citations/23027442	http://purl.uniprot.org/core/author	"Powell R."xsd:string
http://purl.uniprot.org/citations/23027442	http://purl.uniprot.org/core/author	"Obara T."xsd:string
http://purl.uniprot.org/citations/23027442	http://purl.uniprot.org/core/author	"Fukuyo Y."xsd:string
http://purl.uniprot.org/citations/23027442	http://purl.uniprot.org/core/date	"2012"xsd:gYear
http://purl.uniprot.org/citations/23027442	http://purl.uniprot.org/core/name	"Dev Dyn"xsd:string
http://purl.uniprot.org/citations/23027442	http://purl.uniprot.org/core/pages	"1922-1932"xsd:string
http://purl.uniprot.org/citations/23027442	http://purl.uniprot.org/core/title	"Structural disorganization of pronephric glomerulus in zebrafish mpp5a/nagie oko mutant."xsd:string
http://purl.uniprot.org/citations/23027442	http://purl.uniprot.org/core/volume	"241"xsd:string
http://purl.uniprot.org/citations/23027442	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/23027442
http://purl.uniprot.org/citations/23027442	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/23027442
http://purl.uniprot.org/uniprot/#_A0A8M9PWK7-mappedCitation-23027442	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23027442
http://purl.uniprot.org/uniprot/#_B3DIW9-mappedCitation-23027442	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23027442
http://purl.uniprot.org/uniprot/#_F1R0K6-mappedCitation-23027442	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23027442
http://purl.uniprot.org/uniprot/#_Q1LVF4-mappedCitation-23027442	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23027442
http://purl.uniprot.org/uniprot/#_Q8JHF4-mappedCitation-23027442	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23027442
http://purl.uniprot.org/uniprot/#_Q90Y46-mappedCitation-23027442	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23027442
http://purl.uniprot.org/uniprot/Q90Y46	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/23027442
http://purl.uniprot.org/uniprot/Q1LVF4	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/23027442
http://purl.uniprot.org/uniprot/B3DIW9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/23027442