| http://purl.uniprot.org/citations/23027925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23027925 | http://www.w3.org/2000/01/rdf-schema#comment | "Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigen-binding lymphocytes in different contexts. It is not known whether this tolerance-immunity switch requires global rewiring of the signaling apparatus or if it can arise from a single molecular change. By introducing individual CARD11 mutations found in human lymphomas into antigen-activated mature B lymphocytes in mice, we find here that lymphoma-derived CARD11 mutations switch the effect of self-antigen from inducing B cell death into T cell-independent proliferation, Blimp1-mediated plasmablast differentiation, and autoantibody secretion. Our findings demonstrate that regulation of CARD11 signaling is a critical switch governing the decision between death and proliferation in antigen-stimulated mature B cells and that mutations in this switch represent a powerful initiator for aberrant B cell responses in vivo."xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20112744"xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/author | "Goodnow C.C."xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/author | "Horikawa K."xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/author | "Nutt S.L."xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/author | "Wang J.Q."xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/author | "Kallies A."xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/author | "Domaschenz H."xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/author | "Fung H.K."xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/author | "Jeelall Y.S."xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/author | "Law H.D."xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/pages | "1907-1917"xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/title | "Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production."xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://purl.uniprot.org/core/volume | "209"xsd:string |
| http://purl.uniprot.org/citations/23027925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23027925 |
| http://purl.uniprot.org/citations/23027925 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23027925 |
| http://purl.uniprot.org/uniprot/#_A0A192GQE0-mappedCitation-23027925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23027925 |
| http://purl.uniprot.org/uniprot/#_A0A192GQF6-mappedCitation-23027925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23027925 |
| http://purl.uniprot.org/uniprot/#_A0A192GQG0-mappedCitation-23027925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23027925 |
| http://purl.uniprot.org/uniprot/#_A0A192GQM1-mappedCitation-23027925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23027925 |
| http://purl.uniprot.org/uniprot/#_A0A192GRC6-mappedCitation-23027925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23027925 |
| http://purl.uniprot.org/uniprot/#_A0A192GRD0-mappedCitation-23027925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23027925 |