| http://purl.uniprot.org/citations/23028372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23028372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23028372 | http://www.w3.org/2000/01/rdf-schema#comment | "Budding yeast centromeres are sequence-defined point centromeres and are, unlike in many other organisms, not embedded in heterochromatin. Here we show that Fun30, a poorly understood SWI/SNF-like chromatin remodeling factor conserved in humans, promotes point centromere function through the formation of correct chromatin architecture at centromeres. Our determination of the genome-wide binding and nucleosome positioning properties of Fun30 shows that this enzyme is consistently enriched over centromeres and that a majority of CENs show Fun30-dependent changes in flanking nucleosome position and/or CEN core micrococcal nuclease accessibility. Fun30 deletion leads to defects in histone variant Htz1 occupancy genome-wide, including at and around most centromeres. FUN30 genetically interacts with CSE4, coding for the centromere-specific variant of histone H3, and counteracts the detrimental effect of transcription through centromeres on chromosome segregation and suppresses transcriptional noise over centromere CEN3. Previous work has shown a requirement for fission yeast and mammalian homologs of Fun30 in heterochromatin assembly. As centromeres in budding yeast are not embedded in heterochromatin, our findings indicate a direct role of Fun30 in centromere chromatin by promoting correct chromatin architecture."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002974"xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002974"xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Miller J.R."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Miller J.R."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Durand-Dubief M."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Durand-Dubief M."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Kent N.A."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Kent N.A."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Paszkiewicz K."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Paszkiewicz K."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Krueger F."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Krueger F."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Varga-Weisz P."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Varga-Weisz P."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Correra R.M."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Correra R.M."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Crawford M.R."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Crawford M.R."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Harris R.R."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Harris R.R."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Petrini E."xsd:string |
| http://purl.uniprot.org/citations/23028372 | http://purl.uniprot.org/core/author | "Petrini E."xsd:string |