| http://purl.uniprot.org/citations/23029087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23029087 | http://www.w3.org/2000/01/rdf-schema#comment | "A functional sphingosine-1-phosphate (S1P) receptor antagonist specifically inhibited the egress of activated allospecific T cells from draining popliteal lymph nodes in alloantigen-sensitised mice. The level of S1P receptor 1 (S1PR1) mRNA was similarly reduced 1 and 3 days after mitogenic activation of T cells. However, the response of these cells to the S1PR1-specific agonist SEW2871 was only reduced on the first day after T cell activation with normal receptor-mediated Akt-phosphorylation restored by day 3. Longitudinal analysis of CD69 expression showed that almost all T cells expressed this antigen on days 1 and 3 after activation. However, the absolute level of cell-surface expression of CD69 peaked on undivided T cells and was then halved by each of the first 3 cycles of mitosis. CD69-specific small interfering RNA (siRNA) reduced the maximal level of CD69 expression by undivided, mitogen-stimulated T cells. These cells retained their capacity to phosphorylate Akt in response to stimulation with SEW2871. These data show that S1P receptors are involved in controlling the egress of activated T cells from lymph nodes, and that S1PR1 function is regulated by the level of T cell surface CD69. They suggest a potential for augmentation of this process to deplete alloreactive effector cells after organ transplantation."xsd:string |
| http://purl.uniprot.org/citations/23029087 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0045548"xsd:string |
| http://purl.uniprot.org/citations/23029087 | http://purl.uniprot.org/core/author | "Ali S."xsd:string |
| http://purl.uniprot.org/citations/23029087 | http://purl.uniprot.org/core/author | "Swan D.J."xsd:string |
| http://purl.uniprot.org/citations/23029087 | http://purl.uniprot.org/core/author | "Kirby J.A."xsd:string |
| http://purl.uniprot.org/citations/23029087 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23029087 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23029087 | http://purl.uniprot.org/core/pages | "e45548"xsd:string |
| http://purl.uniprot.org/citations/23029087 | http://purl.uniprot.org/core/title | "Post-transplant immunosuppression: regulation of the efflux of allospecific effector T cells from lymphoid tissues."xsd:string |
| http://purl.uniprot.org/citations/23029087 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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