| http://purl.uniprot.org/citations/23032906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23032906 | http://www.w3.org/2000/01/rdf-schema#comment | "Background and objectiveThe epigenetic silencing of tumor suppressor genes plays an important role in gliomagenesis. Recently, tissue factor pathway inhibitor 2 (TFPI-2) has been suggested as a tumor suppressor gene involved in tumorigenesis and metastasis in some cancers. However, to date, little is known about the methylation status of TFPI-2 gene in glioblastoma tissues. In this study, we aimed to investigate the methylation status of TFPI-2 promoter and its associations with patient prognosis in glioblastoma.Material and methodsThe methylation status of TFPI-2 was investigated by methylation-specific polymerase chain reaction in 99 glioblastoma patients. The associations between patients' clinical variables and overall survival time were assessed. RESULTS. TFPI-2 was aberrantly methylated in 22.2% (22/99) of glioblastoma tumors, but was not methylated in normal brain samples. The survival of patients with glioblastoma differed significantly between the methylated and unmethylated TFPI-2 groups (P=0.047). The 2-year survival among patients carrying methylated TFPI-2 tumors was significantly lower compared with that of patients with unmethylated TFPI-2 (27% versus 4.7%, P=0.037).ConclusionsThe present work demonstrated that the epigenetic inactivation of TFPI-2 by promoter hypermethylation was a frequent and tumor-specific event in glioblastoma, and TFPI-2 promoter methylation might be considered as a prognostic marker in glioblastoma."xsd:string |
| http://purl.uniprot.org/citations/23032906 | http://purl.uniprot.org/core/author | "Skauminas K."xsd:string |
| http://purl.uniprot.org/citations/23032906 | http://purl.uniprot.org/core/author | "Skiriute D."xsd:string |
| http://purl.uniprot.org/citations/23032906 | http://purl.uniprot.org/core/author | "Tamasauskas A."xsd:string |
| http://purl.uniprot.org/citations/23032906 | http://purl.uniprot.org/core/author | "Vaitkiene P."xsd:string |
| http://purl.uniprot.org/citations/23032906 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23032906 | http://purl.uniprot.org/core/name | "Medicina (Kaunas)"xsd:string |
| http://purl.uniprot.org/citations/23032906 | http://purl.uniprot.org/core/pages | "345-349"xsd:string |
| http://purl.uniprot.org/citations/23032906 | http://purl.uniprot.org/core/title | "Associations between TFPI-2 methylation and poor prognosis in glioblastomas."xsd:string |
| http://purl.uniprot.org/citations/23032906 | http://purl.uniprot.org/core/volume | "48"xsd:string |
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