| http://purl.uniprot.org/citations/23033370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23033370 | http://www.w3.org/2000/01/rdf-schema#comment | "Infiltration of macrophages into the artery wall plays detrimental roles during hypertension by promoting vascular inflammation and endothelial dysfunction, and it occurs via a chemo-attractant action of chemokines on macrophage cytokine receptors. We sought to identify the key chemokine receptors associated with macrophage infiltration into the vascular wall during deoxycorticosterone acetate (DOCA)/salt-induced hypertension in mice and to evaluate the impact of pharmacological inhibition of these receptors on blood pressure and leukocyte accumulation. Mice treated with DOCA/salt for 21 days displayed markedly elevated systolic blood pressure (158 ± 2 versus 114 ± 5 mm Hg in sham group; P<0.0001). Polymerase chain reaction screening via a gene array of 20 chemokine receptors indicated an increased expression of CCR2 in aortas of DOCA/salt-treated mice. Real-time polymerase chain reaction confirmed mRNA upregulation of CCR2 in aortas from DOCA/salt-treated animals and of the CCR2 ligands CCL2, CCL7, CCL8, and CCL12 (all >2-fold versus sham; P<0.05). Flow cytometry revealed 2.9-fold higher macrophage numbers (ie, CD45(+) CD11b(+) F4/80(+) cells) in the aortic wall of DOCA/salt versus sham-treated mice. Intervention with a CCR2 antagonist, INCB3344 (30 mg/kg per day, IP), 10 days after the induction of hypertension with DOCA/salt treatment, reduced the aortic expression of CCR2 mRNA and completely reversed the DOCA/salt-induced influx of macrophages. Importantly, INCB3344 substantially reduced the elevated blood pressure in DOCA/salt-treated mice. Hence, our findings highlight CCR2 as a promising therapeutic target to reduce both macrophage accumulation in the vascular wall and blood pressure in hypertension."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.org/dc/terms/identifier | "doi:10.1161/hypertensionaha.112.201251"xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/author | "Moore J.P."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/author | "Chan C.T."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/author | "Widdop R.E."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/author | "Guida E."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/author | "Jones E.S."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/author | "Drummond G.R."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/author | "Sobey C.G."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/author | "Armitage J.A."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/author | "Ricardo S.D."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/author | "Budzyn K."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/author | "Sakkal S."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/author | "Vinh A."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/author | "Diep H."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/name | "Hypertension"xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/pages | "1207-1212"xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/title | "Reversal of vascular macrophage accumulation and hypertension by a CCR2 antagonist in deoxycorticosterone/salt-treated mice."xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://purl.uniprot.org/core/volume | "60"xsd:string |
| http://purl.uniprot.org/citations/23033370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23033370 |
| http://purl.uniprot.org/citations/23033370 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23033370 |
| http://purl.uniprot.org/uniprot/#_A9Z1Z1-mappedCitation-23033370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23033370 |
| http://purl.uniprot.org/uniprot/#_Q149U7-mappedCitation-23033370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23033370 |