Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/23037145http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23037145http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus (DM). The susceptibility genes responsible for increasing the risk for DR in type 2 diabetes (T2D) were sought in this study.

Methods

A case-control study was carried out, comprising 749 unrelated T2D individuals with (n = 174) and without (n = 575) DR. Genotypic distributions of single nucleotide polymorphisms (SNPs) were determined for subjects with and without DR.

Results

Eight chromosome 6 SNPs, having the most significant differences, were delineated: rs10499298, rs10499299, rs17827966, rs1224329, rs1150790, rs713050, rs2518344 and rs487083; all were associated with genes TMEM217, MRPL14 and GRIK2. After adjusting for the duration of DM and levels of hemoglobin A(1c), the TT genotype of rs713050, and the AG + AA genotypes of rs2518344 and rs10499298, differed significantly between those with and without DR. Haplotype analysis revealed haplotype C-A-C, residing in rs10499299, rs10499298 and rs17827966, to have significant linkage disequilibrium.

Conclusions

We identified new loci on chromosome 6 associated to DR; all loci showed high levels of linkage disequilibrium."xsd:string
http://purl.uniprot.org/citations/23037145http://purl.org/dc/terms/identifier"doi:10.1159/000342616"xsd:string
http://purl.uniprot.org/citations/23037145http://purl.uniprot.org/core/author"Huang Y.C."xsd:string
http://purl.uniprot.org/citations/23037145http://purl.uniprot.org/core/author"Lin J.M."xsd:string
http://purl.uniprot.org/citations/23037145http://purl.uniprot.org/core/author"Lin H.J."xsd:string
http://purl.uniprot.org/citations/23037145http://purl.uniprot.org/core/author"Wu J.Y."xsd:string
http://purl.uniprot.org/citations/23037145http://purl.uniprot.org/core/author"Tsai F.J."xsd:string
http://purl.uniprot.org/citations/23037145http://purl.uniprot.org/core/author"Chen L.A."xsd:string
http://purl.uniprot.org/citations/23037145http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23037145http://purl.uniprot.org/core/name"Ophthalmologica"xsd:string
http://purl.uniprot.org/citations/23037145http://purl.uniprot.org/core/pages"54-60"xsd:string
http://purl.uniprot.org/citations/23037145http://purl.uniprot.org/core/title"Association of genes on chromosome 6, GRIK2 , TMEM217 and TMEM63B (linked to MRPL14 ) with diabetic retinopathy."xsd:string
http://purl.uniprot.org/citations/23037145http://purl.uniprot.org/core/volume"229"xsd:string
http://purl.uniprot.org/citations/23037145http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23037145
http://purl.uniprot.org/citations/23037145http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23037145
http://purl.uniprot.org/uniprot/#_A0A8D9PH75-mappedCitation-23037145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23037145
http://purl.uniprot.org/uniprot/#_A0A804HHV9-mappedCitation-23037145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23037145
http://purl.uniprot.org/uniprot/#_A8K7F0-mappedCitation-23037145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23037145
http://purl.uniprot.org/uniprot/#_A8K0H7-mappedCitation-23037145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23037145
http://purl.uniprot.org/uniprot/#_D7RWZ8-mappedCitation-23037145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23037145
http://purl.uniprot.org/uniprot/#_B7Z8P6-mappedCitation-23037145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23037145
http://purl.uniprot.org/uniprot/#_G3XAD3-mappedCitation-23037145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23037145
http://purl.uniprot.org/uniprot/#_Q13002-mappedCitation-23037145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23037145
http://purl.uniprot.org/uniprot/#_L8E9A1-mappedCitation-23037145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23037145
▶