| http://purl.uniprot.org/citations/23038256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23038256 | http://www.w3.org/2000/01/rdf-schema#comment | "Cholecystokinin (CCK) and its receptor subtypes CCK-1 and -2 have diverse homeostatic functions. CCK-1 and -2 receptors share a common phosphatidylinositol signaling pathway, yet little is known regarding their possible functional coupling. We focused on CCK-mediated Ca(2+) signaling in parvocellular paraventricular nucleus (PVN) cells, which control satiety and other autonomic functions. Analysis of mouse hypothalamic slices demonstrated that the general CCK receptor agonist CCK-8s (10 nM) triggered Ca(2+) transients most significantly in the posterior subregion of the PVN (PaPo). This 10 nM CCK-8s-induced response was absent in CCK-1 receptor knock-out (CCK1R(-/-)) slices, showing that the response is mediated by CCK-1 receptors. CCK-8s concentrations higher than 30 nM triggered a Ca(2+) rise similarly in wild-type and CCK1R(-/-) slices. The large CCK-8s (100 nM)-induced Ca(2+) responses in CCK1R(-/-) slices were blocked by a CCK-2 receptor antagonist (CI-988), whereas those in wild-type slices required a mixture of CI-988 and lorglumide (a CCK-1 receptor antagonist) for complete antagonism. Therefore, CCK-1 and -2 receptors may function synergistically in single PaPo neurons and deletion of CCK-1 receptors may facilitate CCK-2 receptor signaling. This hypothesis was supported by results of real-time RT-PCR, immunofluorescence double labeling and Western blotting assays, which indicated CCK-2 receptor overexpression in PaPo neurons of CCK1R(-/-) mice. Furthermore, behavioral studies showed that intraperitoneal injections of lorglumide up-regulated food accesses in wild-type but not in CCK1R(-/-) mice, whereas CI-988 injections up-regulated food accesses in CCK1R(-/-) but not in wild-type mice. Compensatory CCK signaling via CCK-2 receptors in CCK1R(-/-) mice shed light on currently controversial satiety-controlling mechanisms."xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.416214"xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://purl.uniprot.org/core/author | "Ikeda M."xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://purl.uniprot.org/core/author | "Takeuchi K."xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://purl.uniprot.org/core/author | "Takiguchi S."xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://purl.uniprot.org/core/author | "Ozaki T."xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://purl.uniprot.org/core/author | "Yamoto K."xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://purl.uniprot.org/core/author | "Unno K."xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://purl.uniprot.org/core/author | "Mohammad S."xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://purl.uniprot.org/core/author | "Morioka E."xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23038256 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://purl.uniprot.org/core/pages | "39391-39401"xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://purl.uniprot.org/core/title | "Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons."xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/23038256 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23038256 |
| http://purl.uniprot.org/citations/23038256 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23038256 |
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| http://purl.uniprot.org/uniprot/#_Q3ZB53-mappedCitation-23038256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23038256 |
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| http://purl.uniprot.org/uniprot/#_Q8BKF6-mappedCitation-23038256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23038256 |