| http://purl.uniprot.org/citations/23041311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23041311 | http://www.w3.org/2000/01/rdf-schema#comment | "NF-κB is central for immune response and cell survival, and its deregulation is linked to chronic inflammation and cancer through poorly defined mechanisms. IκBα and A20 are NF-κB target genes and negative feedback regulators. Upon their activation by NF-κB, DSIF is recruited, P-TEFb is released, and their elongating polymerase II (Pol II) C-terminal domain (CTD) remains hypophosphorylated. We show that upon DSIF knockdown, mRNA levels of a subset of NF-κB targets are not diminished; yet much less IκBα and A20 protein are synthesized, and NF-κB activation is abnormally prolonged. Further analysis of IκBα and A20 mRNA revealed that a significant portion is uncapped, unspliced, and retained in the nucleus. Interestingly, the Spt5 C-terminal repeat (CTR) domain involved in elongation stimulation through P-TEFb is dispensable for IκBα and A20 regulation. These findings assign a function for DSIF in cotranscriptional mRNA processing when elongating Pol II is hypophosphorylated and define DSIF as part of the negative feedback regulation of NF-κB."xsd:string |
| http://purl.uniprot.org/citations/23041311 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2012.08.041"xsd:string |
| http://purl.uniprot.org/citations/23041311 | http://purl.uniprot.org/core/author | "Yamaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/23041311 | http://purl.uniprot.org/core/author | "Handa H."xsd:string |
| http://purl.uniprot.org/citations/23041311 | http://purl.uniprot.org/core/author | "Dikstein R."xsd:string |
| http://purl.uniprot.org/citations/23041311 | http://purl.uniprot.org/core/author | "Amir-Zilberstein L."xsd:string |
| http://purl.uniprot.org/citations/23041311 | http://purl.uniprot.org/core/author | "Diamant G."xsd:string |
| http://purl.uniprot.org/citations/23041311 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23041311 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/23041311 | http://purl.uniprot.org/core/pages | "722-731"xsd:string |
| http://purl.uniprot.org/citations/23041311 | http://purl.uniprot.org/core/title | "DSIF restricts NF-kappaB signaling by coordinating elongation with mRNA processing of negative feedback genes."xsd:string |
| http://purl.uniprot.org/citations/23041311 | http://purl.uniprot.org/core/volume | "2"xsd:string |
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