| http://purl.uniprot.org/citations/23041555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23041555 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin-like growth factor binding protein-3 (IGFBP-3) is a multi-functional protein known to induce apoptosis of various cancer cells in an insulin-like growth factor (IGF)-dependent and IGF-independent manner. In our previous study, we found that IGFBP-3 induced apoptosis through the activation of caspases in 786-O cells. In this study, we further examined that whether IGFBP-3 induced apoptosis through the induction of cell cycle arrest in 786-O, A549 and MCF-7 cells. Our results showed that overexpressed IGFBP-3 resulted in typical apoptotic ultrastructures in A549 cells under transmission electron microscope. The result of flow cytometry analysis indicated that IGFBP-3 arrested the cell cycle at G1-S phase in 786-O, A549 and MCF-7 cells. In A549 cells, quantitative real-time PCR and Western blot analysis showed a significant change in the expression of cell cycle-regulated proteins-a decrease in cyclin E1 expression, an increase in p21 expression. These results indicate a possible mechanism for G1 cell cycle arrest by IGFBP-3. Taken together, cyclin E1 and p21 may play important roles in the IGFBP-3-inducing G1 cell cycle arrest and apoptosis in several human cancer cells."xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2012.09.080"xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://purl.uniprot.org/core/author | "Xie Y."xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://purl.uniprot.org/core/author | "Tian H."xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23041555 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://purl.uniprot.org/core/pages | "127-133"xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://purl.uniprot.org/core/title | "Insulin-like factor binding protein-3 promotes the G1 cell cycle arrest in several cancer cell lines."xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://purl.uniprot.org/core/volume | "512"xsd:string |
| http://purl.uniprot.org/citations/23041555 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23041555 |
| http://purl.uniprot.org/citations/23041555 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23041555 |
| http://purl.uniprot.org/uniprot/#_B3KRZ1-mappedCitation-23041555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23041555 |
| http://purl.uniprot.org/uniprot/#_B3KRJ8-mappedCitation-23041555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23041555 |
| http://purl.uniprot.org/uniprot/#_B3KVF9-mappedCitation-23041555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23041555 |
| http://purl.uniprot.org/uniprot/#_A6XNC9-mappedCitation-23041555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23041555 |
| http://purl.uniprot.org/uniprot/#_A6XND0-mappedCitation-23041555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23041555 |
| http://purl.uniprot.org/uniprot/#_A6XND1-mappedCitation-23041555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23041555 |
| http://purl.uniprot.org/uniprot/#_B4DP07-mappedCitation-23041555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23041555 |