| http://purl.uniprot.org/citations/23042150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23042150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23042150 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 17 (IL-17) is important in infection and autoimmunity; how it signals remains poorly understood. In this study, we identified the ubiquitin-specific protease USP25 as a negative regulator of IL-17-mediated signaling and inflammation. Overexpression of USP25 inhibited IL-17-triggered signaling, whereas USP25 deficiency resulted in more phosphorylation of the inhibitor IκBα and kinase Jnk and higher expression of chemokines and cytokines, as well as a prolonged half-life for chemokine CXCL1-encoding mRNA after treatment with IL-17. Consistent with that, Usp25(-/-) mice showed greater sensitivity to IL-17-dependent inflammation and autoimmunity in vivo. Mechanistically, stimulation with IL-17 induced the association of USP25 with the adaptors TRAF5 and TRAF6, and USP25 induced removal of Lys63-linked ubiquitination in TRAF5 and TRAF6 mediated by the adaptor Act1. Thus, our results demonstrate that USP25 is a deubiquitinating enzyme (DUB) that negatively regulates IL-17-triggered signaling."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2427"xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2427"xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Wang A."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Wang A."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Zhong B."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Zhong B."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Chang S.H."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Chang S.H."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Liu X.'"xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Liu X.'"xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Reynolds J.M."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/author | "Reynolds J.M."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/23042150 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |