| http://purl.uniprot.org/citations/23042269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23042269 | http://www.w3.org/2000/01/rdf-schema#comment | "p130cas (p130 Crk-associated substrate) is a scaffolding protein and plays an important role in regulating focal adhesion and driving cell migration. Also, the destruction of E-cadherin/β-catenin adhesive complex is one of the changes that characterizes the invasive phenotype of tumors. The aim of this study is to evaluate the role of p130cas, E-cadherin, and β-catenin expression in patients with non-small cell lung cancer (NSCLC). We examined the expression of p130cas, E-cadherin, and β-catenin in 105 lung cancer tissues and paired adjacent normal lung tissues using immunohistochemistry. The overexpression of p130cas was observed in 61.9% (65/105) of lung cancer samples. The overexpression of p130cas was correlated with abnormal expression of E-cadherin and β-catenin (P=0.002 and P=0.006, respectively). Chi-square test showed that the overexpression of p130cas correlated positively with lymph node metastasis and high TNM stage. The Log-Rank test revealed that the mean survival time of patients with p130cas overexpression (36.31 ± 5.66 months) was markedly shorter than those with p130cas normal expression (60.57 ± 6.95 months). Multivariable analysis indicated p130cas overexpression (P<0.001) as an independent significant prognostic factor for NSCLC patients' survival. These results indicate that p130cas may impact a variety of clinicopathological features of NSCLC and may y influence the prognosis of lung cancer patients."xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.org/dc/terms/identifier | "doi:10.5603/11957"xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/author | "Han Y."xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/author | "Wang E."xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/author | "Miao Y."xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/author | "Zhang X.P."xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/author | "Li A.L."xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/author | "Xu H.T."xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/author | "Fan C.F."xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/name | "Folia Histochem Cytobiol"xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/pages | "392-397"xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/title | "Expression of p130cas, E-cadherin and beta-catenin and their correlation with clinicopathological parameters in non-small cell lung cancer: p130cas over-expression predicts poor prognosis."xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/23042269 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23042269 |
| http://purl.uniprot.org/citations/23042269 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23042269 |
| http://purl.uniprot.org/uniprot/#_A0A0E3XJU3-mappedCitation-23042269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23042269 |
| http://purl.uniprot.org/uniprot/#_A0A0U2ZQU7-mappedCitation-23042269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23042269 |
| http://purl.uniprot.org/uniprot/#_A0A140HMB1-mappedCitation-23042269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23042269 |
| http://purl.uniprot.org/uniprot/#_P56945-mappedCitation-23042269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23042269 |
| http://purl.uniprot.org/uniprot/#_A0A3G2JNR5-mappedCitation-23042269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23042269 |
| http://purl.uniprot.org/uniprot/#_A0A6C0N5X1-mappedCitation-23042269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23042269 |