| http://purl.uniprot.org/citations/23042605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23042605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23042605 | http://www.w3.org/2000/01/rdf-schema#comment | "Ubiquitin-mediated processes orchestrate critical DNA-damage signaling and repair pathways. We identify human DVC1 (C1orf124; Spartan) as a cell cycle-regulated anaphase-promoting complex (APC) substrate that accumulates at stalled replication forks. DVC1 recruitment to sites of replication stress requires its ubiquitin-binding UBZ domain and PCNA-binding PIP box motif but is independent of RAD18-mediated PCNA monoubiquitylation. Via a conserved SHP box, DVC1 recruits the ubiquitin-selective chaperone p97 to blocked replication forks, which may facilitate p97-dependent removal of translesion synthesis (TLS) DNA polymerase η (Pol η) from monoubiquitylated PCNA. DVC1 knockdown enhances UV light-induced mutagenesis, and depletion of human DVC1 or the Caenorhabditis elegans ortholog DVC-1 causes hypersensitivity to replication stress-inducing agents. Our findings establish DVC1 as a DNA damage-targeting p97 adaptor that protects cells from deleterious consequences of replication blocks and suggest an important role of p97 in ubiquitin-dependent regulation of TLS."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2395"xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2395"xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Choudhary C."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Choudhary C."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Hartmann-Petersen R."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Hartmann-Petersen R."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Lukas C."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Lukas C."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Lukas J."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Lukas J."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Bekker-Jensen S."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Bekker-Jensen S."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Mailand N."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Mailand N."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Thorslund T."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Thorslund T."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Beli P."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Beli P."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Povlsen L."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Povlsen L."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Kagias K."xsd:string |
| http://purl.uniprot.org/citations/23042605 | http://purl.uniprot.org/core/author | "Kagias K."xsd:string |