| http://purl.uniprot.org/citations/23042675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23042675 | http://www.w3.org/2000/01/rdf-schema#comment | "During mammalian base excision repair (BER) of lesion-containing DNA, it is proposed that toxic strand-break intermediates generated throughout the pathway are sequestered and passed from one step to the next until repair is complete. This stepwise process is termed substrate channeling. A working model evaluated here is that a complex of BER factors may facilitate the BER process. FLAG-tagged DNA polymerase (pol) β was expressed in mouse fibroblasts carrying a deletion in the endogenous pol β gene, and the cell extract was subjected to an 'affinity-capture' procedure using anti-FLAG antibody. The pol β affinity-capture fraction (ACF) was found to contain several BER factors including polymerase-1, X-ray cross-complementing factor1-DNA ligase III and enzymes involved in processing 3'-blocked ends of BER intermediates, e.g. polynucleotide kinase and tyrosyl-DNA phosphodiesterase 1. In contrast, DNA glycosylases, apurinic/aprymidinic endonuclease 1 and flap endonuclease 1 and several other factors involved in BER were not present. Some of the BER factors in the pol β ACF were in a multi-protein complex as observed by sucrose gradient centrifugation. The pol β ACF was capable of substrate channeling for steps in vitro BER and was proficient in in vitro repair of substrates mimicking a 3'-blocked topoisomerase I covalent intermediate or an oxidative stress-induced 3'-blocked intermediate."xsd:string |
| http://purl.uniprot.org/citations/23042675 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gks898"xsd:string |
| http://purl.uniprot.org/citations/23042675 | http://purl.uniprot.org/core/author | "Williams J.G."xsd:string |
| http://purl.uniprot.org/citations/23042675 | http://purl.uniprot.org/core/author | "Prasad R."xsd:string |
| http://purl.uniprot.org/citations/23042675 | http://purl.uniprot.org/core/author | "Wilson S.H."xsd:string |
| http://purl.uniprot.org/citations/23042675 | http://purl.uniprot.org/core/author | "Hou E.W."xsd:string |
| http://purl.uniprot.org/citations/23042675 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23042675 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/23042675 | http://purl.uniprot.org/core/pages | "11571-11582"xsd:string |
| http://purl.uniprot.org/citations/23042675 | http://purl.uniprot.org/core/title | "Pol beta associated complex and base excision repair factors in mouse fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/23042675 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/23042675 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23042675 |
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