| http://purl.uniprot.org/citations/23042680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23042680 | http://www.w3.org/2000/01/rdf-schema#comment | "We examined the mechanism regulating the cellular levels of PNKP, the major kinase/phosphatase involved in the repair of oxidative DNA damage, and find that it is controlled by ATM phosphorylation and ubiquitylation-dependent proteasomal degradation. We discovered that ATM-dependent phosphorylation of PNKP at serines 114 and 126 in response to oxidative DNA damage inhibits ubiquitylation-dependent proteasomal degradation of PNKP, and consequently increases PNKP stability that is required for DNA repair. We have also purified a novel Cul4A-DDB1 ubiquitin ligase complex responsible for PNKP ubiquitylation and identify serine-threonine kinase receptor associated protein (STRAP) as the adaptor protein that provides specificity of the complex to PNKP. Strap(-/-) mouse embryonic fibroblasts subsequently contain elevated cellular levels of PNKP, and show elevated resistance to oxidative DNA damage. These data demonstrate an important role for ATM and the Cul4A-DDB1-STRAP ubiquitin ligase in the regulation of the cellular levels of PNKP, and consequently in the repair of oxidative DNA damage."xsd:string |
| http://purl.uniprot.org/citations/23042680 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gks909"xsd:string |
| http://purl.uniprot.org/citations/23042680 | http://purl.uniprot.org/core/author | "Datta P.K."xsd:string |
| http://purl.uniprot.org/citations/23042680 | http://purl.uniprot.org/core/author | "Kessler B.M."xsd:string |
| http://purl.uniprot.org/citations/23042680 | http://purl.uniprot.org/core/author | "Ternette N."xsd:string |
| http://purl.uniprot.org/citations/23042680 | http://purl.uniprot.org/core/author | "Dianov G.L."xsd:string |
| http://purl.uniprot.org/citations/23042680 | http://purl.uniprot.org/core/author | "Dianova I.I."xsd:string |
| http://purl.uniprot.org/citations/23042680 | http://purl.uniprot.org/core/author | "Khoronenkova S.V."xsd:string |
| http://purl.uniprot.org/citations/23042680 | http://purl.uniprot.org/core/author | "Parsons J.L."xsd:string |
| http://purl.uniprot.org/citations/23042680 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23042680 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/23042680 | http://purl.uniprot.org/core/pages | "11404-11415"xsd:string |
| http://purl.uniprot.org/citations/23042680 | http://purl.uniprot.org/core/title | "Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/23042680 | http://purl.uniprot.org/core/volume | "40"xsd:string |
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