| http://purl.uniprot.org/citations/2304550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2304550 | http://www.w3.org/2000/01/rdf-schema#comment | "The antigen receptors on mature B lymphocytes are membrane-bound immunoglobulins of the IgM and IgD classes whose cross-linking by polyvalent antigens results in B-cell proliferation and differentiation. How these membrane-bound immunoglobulin chains, which lack a cytoplasmic tail, generate a cell activation signal is not at present known. We now show that the IgM molecule is non-covalently associated in the membrane of B cells with two proteins of relative molecular mass 34,000 (Mr 34 K; IgM-alpha) and 39 K (Ig-beta) which form a disulphide-linked heterodimer. Surface expression of IgM seems to require the formation of an appropriate complex between IgM and the heterodimer. A transfection experiment indicates that IgM-alpha is the product of mb-1, a B-cell specific gene encoding a transmembrane protein with sequence homology to proteins of the T-cell antigen receptor-CD3 complex."xsd:string |
| http://purl.uniprot.org/citations/2304550 | http://purl.org/dc/terms/identifier | "doi:10.1038/343760a0"xsd:string |
| http://purl.uniprot.org/citations/2304550 | http://purl.uniprot.org/core/author | "Reth M."xsd:string |
| http://purl.uniprot.org/citations/2304550 | http://purl.uniprot.org/core/author | "Leclercq L."xsd:string |
| http://purl.uniprot.org/citations/2304550 | http://purl.uniprot.org/core/author | "Tsubata T."xsd:string |
| http://purl.uniprot.org/citations/2304550 | http://purl.uniprot.org/core/author | "Hombach J."xsd:string |
| http://purl.uniprot.org/citations/2304550 | http://purl.uniprot.org/core/author | "Stappert H."xsd:string |
| http://purl.uniprot.org/citations/2304550 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2304550 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/2304550 | http://purl.uniprot.org/core/pages | "760-762"xsd:string |
| http://purl.uniprot.org/citations/2304550 | http://purl.uniprot.org/core/title | "Molecular components of the B-cell antigen receptor complex of the IgM class."xsd:string |
| http://purl.uniprot.org/citations/2304550 | http://purl.uniprot.org/core/volume | "343"xsd:string |
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