| http://purl.uniprot.org/citations/23045604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23045604 | http://www.w3.org/2000/01/rdf-schema#comment | "Innate immune detection of nucleic acids is important for initiation of antiviral responses. Detection of intracellular DNA activates STING-dependent type I interferons (IFNs) and the ASC-dependent inflammasome. Certain members of the AIM2-like receptor (ALR) gene family contribute to each of these pathways, but most ALRs remain uncharacterized. Here, we identify five novel murine ALRs and perform a phylogenetic analysis of mammalian ALRs, revealing a remarkable diversification of these receptors among mammals. We characterize the expression, localization, and functions of the murine and human ALRs and identify novel activators of STING-dependent IFNs and the ASC-dependent inflammasome. These findings validate ALRs as key activators of the antiviral response and provide an evolutionary and functional framework for understanding their roles in innate immunity."xsd:string |
| http://purl.uniprot.org/citations/23045604 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20121960"xsd:string |
| http://purl.uniprot.org/citations/23045604 | http://purl.uniprot.org/core/author | "Young J.M."xsd:string |
| http://purl.uniprot.org/citations/23045604 | http://purl.uniprot.org/core/author | "Malik H.S."xsd:string |
| http://purl.uniprot.org/citations/23045604 | http://purl.uniprot.org/core/author | "Brunette R.L."xsd:string |
| http://purl.uniprot.org/citations/23045604 | http://purl.uniprot.org/core/author | "Stetson D.B."xsd:string |
| http://purl.uniprot.org/citations/23045604 | http://purl.uniprot.org/core/author | "Brodsky I.E."xsd:string |
| http://purl.uniprot.org/citations/23045604 | http://purl.uniprot.org/core/author | "Whitley D.G."xsd:string |
| http://purl.uniprot.org/citations/23045604 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23045604 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/23045604 | http://purl.uniprot.org/core/pages | "1969-1983"xsd:string |
| http://purl.uniprot.org/citations/23045604 | http://purl.uniprot.org/core/title | "Extensive evolutionary and functional diversity among mammalian AIM2-like receptors."xsd:string |
| http://purl.uniprot.org/citations/23045604 | http://purl.uniprot.org/core/volume | "209"xsd:string |
| http://purl.uniprot.org/citations/23045604 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23045604 |
| http://purl.uniprot.org/citations/23045604 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23045604 |
| http://purl.uniprot.org/uniprot/#_A0A125R9I3-mappedCitation-23045604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23045604 |
| http://purl.uniprot.org/uniprot/#_A0A087WQG9-mappedCitation-23045604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23045604 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXV9-mappedCitation-23045604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23045604 |
| http://purl.uniprot.org/uniprot/#_D0QMC3-mappedCitation-23045604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23045604 |
| http://purl.uniprot.org/uniprot/#_A0A087WSH9-mappedCitation-23045604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23045604 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0H6-mappedCitation-23045604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23045604 |
| http://purl.uniprot.org/uniprot/#_E9QAN9-mappedCitation-23045604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23045604 |
| http://purl.uniprot.org/uniprot/#_A0A087WRA4-mappedCitation-23045604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23045604 |
| http://purl.uniprot.org/uniprot/#_D3Z2E7-mappedCitation-23045604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23045604 |