| http://purl.uniprot.org/citations/23045606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23045606 | http://www.w3.org/2000/01/rdf-schema#comment | "Infiltration of Foxp3(+) regulatory T (T reg) cells is considered to be a critical step during tumor development and progression. T reg cells supposedly suppress locally an effective anti-tumor immune response within tumor tissues, although the precise mechanism by which T reg cells infiltrate the tumor is still unclear. We provide evidence that Neuropilin 1 (Nrp-1), highly expressed by Foxp3(+) T reg cells, regulates the immunological anti-tumor control by guiding T reg cells into the tumor in response to tumor-derived vascular endothelial growth factor (VEGF). We demonstrate for the first time that T cell-specific ablation of Nrp-1 expression results in a significant breakdown in tumor immune escape in various transplantation models and in a spontaneous, endogenously driven melanoma model associated with strongly reduced tumor growth and prolonged tumor-free survival. Strikingly, numbers of tumor-infiltrating Foxp3(+) T reg cells were significantly reduced accompanied by enhanced activation of CD8(+) T cells within tumors of T cell-specific Nrp-1-deficient mice. This phenotype can be reversed by adoptive transfer of Nrp-1(+) T reg cells from wild-type mice. Thus, our data strongly suggest that Nrp-1 acts as a key mediator of Foxp3(+) T reg cell infiltration into the tumor site resulting in a dampened anti-tumor immune response and enhanced tumor progression."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20111497"xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/author | "Abel S."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/author | "Sakaguchi S."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/author | "Albert J."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/author | "Kliche S."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/author | "Schadendorf D."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/author | "Sparwasser T."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/author | "Buer J."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/author | "Hutzler M."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/author | "Stockmann C."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/author | "Hansen W."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/author | "Helfrich I."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/author | "Westendorf A.M."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/author | "Alter C."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/pages | "2001-2016"xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/title | "Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth."xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://purl.uniprot.org/core/volume | "209"xsd:string |
| http://purl.uniprot.org/citations/23045606 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23045606 |
| http://purl.uniprot.org/citations/23045606 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23045606 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-23045606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23045606 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC46-mappedCitation-23045606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23045606 |