| http://purl.uniprot.org/citations/23047894 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23047894 | http://www.w3.org/2000/01/rdf-schema#comment | "Adipose tissues regulate metabolism, reproduction, and life span. The development and growth of adipose tissue are due to increases of both adipocyte cell size and cell number; the latter is mediated by adipocyte progenitors. Various markers have been used to identify either adipocyte progenitors or mature adipocytes. The fatty acid binding protein 4 (FABP4), commonly known as adipocyte protein 2 (aP2), has been extensively used as a marker for differentiated adipocytes. However, whether aP2 is expressed in adipogenic progenitors is controversial. Using Cre/LoxP-based cell lineage tracing in mice, we have identified a population of aP2-expressing progenitors in the stromal vascular fraction (SVF) of both white and brown adipose tissues. The aP2-lineage progenitors reside in the adipose stem cell niche and express adipocyte progenitor markers, including CD34, Sca1, Dlk1, and PDGFRα. When isolated and grown in culture, the aP2-expressing SVF cells proliferate and differentiate into adipocytes upon induction. Conversely, ablation of the aP2 lineage greatly reduces the adipogenic potential of SVF cells. When grafted into wild-type mice, the aP2-lineage progenitors give rise to adipose depots in recipient mice. Therefore, the expression of aP2 is not limited to mature adipocytes, but also marks a pool of undifferentiated progenitors associated with the vasculature of adipose tissues. Our finding adds to the repertoire of adipose progenitor markers and points to a new regulator of adipose plasticity."xsd:string |
| http://purl.uniprot.org/citations/23047894 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.12-211516"xsd:string |
| http://purl.uniprot.org/citations/23047894 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/23047894 | http://purl.uniprot.org/core/author | "Shan T."xsd:string |
| http://purl.uniprot.org/citations/23047894 | http://purl.uniprot.org/core/author | "Kuang S."xsd:string |
| http://purl.uniprot.org/citations/23047894 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23047894 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/23047894 | http://purl.uniprot.org/core/pages | "277-287"xsd:string |
| http://purl.uniprot.org/citations/23047894 | http://purl.uniprot.org/core/title | "Fatty acid binding protein 4 expression marks a population of adipocyte progenitors in white and brown adipose tissues."xsd:string |
| http://purl.uniprot.org/citations/23047894 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/23047894 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23047894 |
| http://purl.uniprot.org/citations/23047894 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23047894 |
| http://purl.uniprot.org/uniprot/#_Q99M00-mappedCitation-23047894 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23047894 |
| http://purl.uniprot.org/uniprot/#_P04117-mappedCitation-23047894 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23047894 |
| http://purl.uniprot.org/uniprot/#_Q542H7-mappedCitation-23047894 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23047894 |
| http://purl.uniprot.org/uniprot/P04117 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23047894 |
| http://purl.uniprot.org/uniprot/Q542H7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23047894 |
| http://purl.uniprot.org/uniprot/Q99M00 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23047894 |