| http://purl.uniprot.org/citations/23054006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23054006 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to type 1 diabetes (T1D). We conducted a meta-analysis of the transmission disequilibrium test (TDT) examining preferential transmission of the T allele of the PTPN22 C1858T polymorphism to children with T1D. A total of 11 studies were included in this meta-analysis, which contained 3,946 families and 2,024 transmissions of the PTPN22 T allele in 11 European populations. The frequencies of the transmitted and non-transmitted T allele were 1,250 (61.8 %) and 774 (38.2 %), respectively. The T allele was transmitted to T1D offspring more often than expected. Meta-analysis showed a significant association between the PTPN22 T allele and T1D (OR 1.611, 95 % CI 1.421, 1.827, p < 1 × 10(-8)) without between-study heterogeneity (I(2) = 32.5, p = 0.138). Publication bias was observed in this meta-analysis (Egger's regression test, p-values = 0.061), but the adjusted OR calculated using the trim and fill technique remained significant (OR 1.577, 95 % CI 1.392, 1.785). This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans."xsd:string |
| http://purl.uniprot.org/citations/23054006 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11033-012-2051-8"xsd:string |
| http://purl.uniprot.org/citations/23054006 | http://purl.uniprot.org/core/author | "Lee Y.H."xsd:string |
| http://purl.uniprot.org/citations/23054006 | http://purl.uniprot.org/core/author | "Song G.G."xsd:string |
| http://purl.uniprot.org/citations/23054006 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23054006 | http://purl.uniprot.org/core/name | "Mol Biol Rep"xsd:string |
| http://purl.uniprot.org/citations/23054006 | http://purl.uniprot.org/core/pages | "211-215"xsd:string |
| http://purl.uniprot.org/citations/23054006 | http://purl.uniprot.org/core/title | "Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/23054006 | http://purl.uniprot.org/core/volume | "40"xsd:string |
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