| http://purl.uniprot.org/citations/23055200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23055200 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to evaluate the association between activating enhancer binding protein 4 (AP-4) tissue expression and patient prognosis in hepatocellular carcinoma (HCC). The levels of AP-4 mRNA and protein in tumor and para-tumor tissue were evaluated in 30 HCC cases by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot. Additionally, AP-4 protein expression in 112 HCC was analyzed by immunohistochemistry. The correlation of AP-4 expression and patients' clinicopathological parameters was evaluated. Survival analysis was performed using the Kaplan-Meier method and Cox's proportional hazards model. By RT-PCR and Western blot, the levels of AP-4 mRNA and protein were significantly higher in HCC, compared to that in para-tumor tissue (p < 0.001). Immunohistochemical staining revealed that AP-4 was highly expressed in 53.6 % of the HCC patients. The AP-4 expression level was closely associated with serum alpha fetoprotein elevation, tumor size, histological differentiation, tumor recurrence, tumor metastasis, and tumor stage. Kaplan-Meier survival analysis showed that a high expression level of AP-4 resulted in a significantly poor prognosis of HCC patients. Multivariate analysis revealed that AP-4 expression level was an independent prognostic parameter for the overall survival rate of HCC patients. These findings provide evidence that a high expression level of AP-4 serves as a biomarker for poor prognosis for HCC. Thus, we speculate that AP-4 may be a potential target of antiangiogenic therapy for HCC."xsd:string |
| http://purl.uniprot.org/citations/23055200 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13277-012-0547-4"xsd:string |
| http://purl.uniprot.org/citations/23055200 | http://purl.uniprot.org/core/author | "Zhao G."xsd:string |
| http://purl.uniprot.org/citations/23055200 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/23055200 | http://purl.uniprot.org/core/author | "Dong J.H."xsd:string |
| http://purl.uniprot.org/citations/23055200 | http://purl.uniprot.org/core/author | "Tan J.W."xsd:string |
| http://purl.uniprot.org/citations/23055200 | http://purl.uniprot.org/core/author | "Yu H.F."xsd:string |
| http://purl.uniprot.org/citations/23055200 | http://purl.uniprot.org/core/author | "Hu B.S."xsd:string |
| http://purl.uniprot.org/citations/23055200 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23055200 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/23055200 | http://purl.uniprot.org/core/pages | "271-276"xsd:string |
| http://purl.uniprot.org/citations/23055200 | http://purl.uniprot.org/core/title | "High expression of AP-4 predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy."xsd:string |
| http://purl.uniprot.org/citations/23055200 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/23055200 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23055200 |
| http://purl.uniprot.org/citations/23055200 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23055200 |
| http://purl.uniprot.org/uniprot/#_Q01664-mappedCitation-23055200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23055200 |
| http://purl.uniprot.org/uniprot/#_Q59GG3-mappedCitation-23055200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23055200 |
| http://purl.uniprot.org/uniprot/#_Q6FHM5-mappedCitation-23055200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23055200 |
| http://purl.uniprot.org/uniprot/Q6FHM5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23055200 |
| http://purl.uniprot.org/uniprot/Q59GG3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23055200 |
| http://purl.uniprot.org/uniprot/Q01664 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23055200 |