| http://purl.uniprot.org/citations/23059983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23059983 | http://www.w3.org/2000/01/rdf-schema#comment | "Development of contact allergy requires cooperation of adaptive and innate immunity. Ni(2+) stimulates innate immunity via TLR4/MD2, the bacterial LPS receptor. This likely involves receptor dimerization, but direct proof is pending and it is unclear if related haptens share this mechanism. We reveal Co(2+) as second metal stimulating TLR4 and confirm necessity of H456/H458 therein. Experiments with a new TLR4 dimerization mutant established dimerization as a mechanism of metal- and LPS-induced TLR4 activation. Yet, in interaction studies only LPS-but not metal-induced dimerization required MD2. Consistently, soluble TLR4 expressed without MD2 inhibited metal-but not LPS-induced responses, opening new therapeutic perspectives."xsd:string |
| http://purl.uniprot.org/citations/23059983 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2012.155"xsd:string |
| http://purl.uniprot.org/citations/23059983 | http://purl.uniprot.org/core/author | "Schmidt M."xsd:string |
| http://purl.uniprot.org/citations/23059983 | http://purl.uniprot.org/core/author | "Martin S.F."xsd:string |
| http://purl.uniprot.org/citations/23059983 | http://purl.uniprot.org/core/author | "Goebeler M."xsd:string |
| http://purl.uniprot.org/citations/23059983 | http://purl.uniprot.org/core/author | "Raghavan B."xsd:string |
| http://purl.uniprot.org/citations/23059983 | http://purl.uniprot.org/core/author | "Esser P.R."xsd:string |
| http://purl.uniprot.org/citations/23059983 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23059983 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/23059983 | http://purl.uniprot.org/core/pages | "1109-1115"xsd:string |
| http://purl.uniprot.org/citations/23059983 | http://purl.uniprot.org/core/title | "Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2."xsd:string |
| http://purl.uniprot.org/citations/23059983 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/23059983 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23059983 |
| http://purl.uniprot.org/citations/23059983 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23059983 |
| http://purl.uniprot.org/uniprot/O00206#attribution-E7A0B2FCA15A8768BBC479B693DF094D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23059983 |
| http://purl.uniprot.org/uniprot/#_O00206-mappedCitation-23059983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23059983 |
| http://purl.uniprot.org/uniprot/#_Q9Y6Y9-mappedCitation-23059983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23059983 |
| http://purl.uniprot.org/uniprot/O00206 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23059983 |
| http://purl.uniprot.org/uniprot/Q9Y6Y9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23059983 |